Molecular characterisation of rifampicin-resistant mycobacterium tuberculosis strains from morocco

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dc.contributor.authorKourout M.
dc.contributor.authorChaoui I.
dc.contributor.authorSabouni R.
dc.contributor.authorLahlou O.
dc.contributor.authorEl Mzibri M.
dc.contributor.authorJordaan A.
dc.contributor.authorVictor T.C.
dc.contributor.authorAkrim M.
dc.contributor.authorEl Aouad R.
dc.date.accessioned2011-05-15T15:53:46Z
dc.date.available2011-05-15T15:53:46Z
dc.date.issued2009
dc.description.abstractMutations in the rpoB gene associated with rifampicin (RMP) resistance were studied in 47 RMP-resistant and 147 RMP-susceptible clinical strains of Mycobacterium tuberculosis from Morocco using probe-based assay and DNA sequencing. RMP-resistant mutations were identi-fi ed in 85% of RMP-resistant isolates. No mutations were observed among the 147 RMP-susceptible strains. Sequence analysis identifi ed 10 alleles, including two deletions not previously reported. Nucleotide changes at codons 531, 526 and 516 were the most prominent, accounting for 74.4% of our RMP-resistant strains. These results demonstrate that resistance genotyping at these codons would be a good marker for the rapid detection of RMP resistance. © 2009 The Union.
dc.description.versionArticle
dc.identifier.citationInternational Journal of Tuberculosis and Lung Disease
dc.identifier.citation13
dc.identifier.citation11
dc.identifier.issn10273719
dc.identifier.urihttp://hdl.handle.net/10019.1/8804
dc.titleMolecular characterisation of rifampicin-resistant mycobacterium tuberculosis strains from morocco
dc.typeArticle
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