Population structure of multi- and extensively drug-resistant Mycobacterium tuberculosis strains in South Africa

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dc.contributor.authorChihota V.N.
dc.contributor.authorMuller B.
dc.contributor.authorMlambo C.K.
dc.contributor.authorPillay M.
dc.contributor.authorTait M.
dc.contributor.authorStreicher E.M.
dc.contributor.authorMarais E.
dc.contributor.authorVan Der Spuy G.D.
dc.contributor.authorHanekom M.
dc.contributor.authorCoetzee G.
dc.contributor.authorTrollip A.
dc.contributor.authorHayes C.
dc.contributor.authorBosman M.E.
dc.contributor.authorGey Van Pittius N.C.
dc.contributor.authorVictor T.C.
dc.contributor.authorVan Helden P.D.
dc.contributor.authorWarren R.M.
dc.date.accessioned2012-04-12T08:21:53Z
dc.date.available2012-04-12T08:21:53Z
dc.date.issued2012
dc.description.abstractGenotyping of multidrug-resistant (MDR) Mycobacterium tuberculosis strains isolated from tuberculosis (TB) patients in four South African provinces (Western Cape, Eastern Cape, KwaZulu-Natal, and Gauteng) revealed a distinct population structure of the MDR strains in all four regions, despite the evidence of substantial human migration between these settings. In all analyzed provinces, a negative correlation between strain diversity and an increasing level of drug resistance (from MDR-TB to extensively drug-resistant TB [XDR-TB]) was observed. Strains predominating in XDR-TB in the Western and Eastern Cape and KwaZulu-Natal Provinces were strongly associated with harboring an inhA promoter mutation, potentially suggesting a role of these mutations in XDR-TB development in South Africa. Approximately 50% of XDR-TB cases detected in the Western Cape were due to strains probably originating from the Eastern Cape. This situation may illustrate how failure of efficient health care delivery in one setting can burden health clinics in other areas. Copyright © 2012, American Society for Microbiology. All Rights Reserved.
dc.identifier.citationJournal of Clinical Microbiology
dc.identifier.citation50
dc.identifier.citation3
dc.identifier.citation995
dc.identifier.citation1002
dc.identifier.issn951137
dc.identifier.other10.1128/JCM.05832-11
dc.identifier.urihttp://hdl.handle.net/10019.1/20605
dc.titlePopulation structure of multi- and extensively drug-resistant Mycobacterium tuberculosis strains in South Africa
dc.typeArticle
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