The relationship of anticardiolipin antibodies to disease activity in systemic lupus erythematosus

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dc.contributor.authorCooper R.C.
dc.contributor.authorKlemp P.
dc.contributor.authorStipp C.J.
dc.contributor.authorBrink S.
dc.date.accessioned2011-05-15T16:15:49Z
dc.date.available2011-05-15T16:15:49Z
dc.date.issued1989
dc.description.abstractSera from 124 blood donors, 60 rheumatoid arthritis (RA) and 57 SLE patients were measured for anticardiolipin antibodies by ELISA. Significantly raised IgG (aCLG) and IgM (aCLM) anticardiolipin antibody levels were found in RA and SLE (p < 0.0005). However, in SLE, both aCLG and aCLM levels were significantly higher than in RA (p < 0.0025). We then conducted a transectional study to evaluate aCL levels and disease activity in SLE. There was a good positive predictive value (70%) between aCL and overall disease activity, but not for individual systems. A strong association between aCL and renal involvement irrespective of activity was also found (80%). Nine SLE patients fulfilled both the clinical and serological criteria for the antiphospholipid syndrome (APS) and a further 18 patients fulfilled the serological criteria for APS. Results indicate that aCL levels are of value in predicting overall disease activity in SLE and in monitoring those patients who fulfil or partially fulfil the criteria for APS.
dc.description.versionArticle
dc.identifier.citationBritish Journal of Rheumatology
dc.identifier.citation28
dc.identifier.citation5
dc.identifier.issn02637103
dc.identifier.urihttp://hdl.handle.net/10019.1/13502
dc.subjectcardiolipin antibody
dc.subjectadult
dc.subjectaged
dc.subjectcontrolled study
dc.subjectdisease activity
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpriority journal
dc.subjectrheumatoid arthritis
dc.subjectsystemic lupus erythematosus
dc.subjectthrombocytopenia
dc.subjectthromboplastin time
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectArthritis, Rheumatoid
dc.subjectAutoantibodies
dc.subjectCardiolipins
dc.subjectEnzyme-Linked Immunosorbent Assay
dc.subjectFemale
dc.subjectHuman
dc.subjectImmunoglobulin G
dc.subjectImmunoglobulin M
dc.subjectKidney Diseases
dc.subjectLupus Erythematosus, Systemic
dc.subjectMale
dc.subjectMiddle Age
dc.subjectPredictive Value of Tests
dc.subjectSupport, Non-U.S. Gov't
dc.titleThe relationship of anticardiolipin antibodies to disease activity in systemic lupus erythematosus
dc.typeArticle
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