Effect of chronic desipramine treatment on neurotransmitter-thyrotropin releasing hormone - thyrotropin interactions in the rat

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dc.contributor.authorJaffer A.
dc.contributor.authorRussell V.A.
dc.contributor.authorTaljaard J.J.F.
dc.date.accessioned2011-05-15T16:17:28Z
dc.date.available2011-05-15T16:17:28Z
dc.date.issued1987
dc.description.abstractLong-term administration of the antidepressant drug, desipramine (20 mg/kg/day, orally for 28 days), decreased the stimulatory effect of the α2-adrenoceptor agonist, clonidine (250 μg/kg, i.p.) on thyrotropin (TSH) secretion in the rat, but did not alter basal TSH secretion. β-Adrenoceptor-mediated inhibition of TSH secretion by isoproterenol (1 mg/kg, i.p.) was unaffected by chronic desipramine treatment, as were the stimulatory effect of TSH-releasing hormone (TRH, 5 μg/kg, i.v.) on TSH release and its inhibition by the α-adrenoceptor antagonist, phentolamine (2 mg/kg, i.p.). These findings suggest that chronic desipramine treatment induces subsensitivity of α2-adrenoceptors which modulate TSH secretion in the rat while not affecting β2-adrenoceptor-mediated inhibition of TSH release. These findings suggest that pituitary TRH receptors are unchanged but that changes occurred at the hypothalamic level in α2-adrenoceptor-mediated stimulation of TRH release. Although cerebral β-adrenoceptors have been shown convincingly to be down-regulated after chronic desipramine treatment, their function in the hypothalamic TRH system after 28 days of treatment with desipramine appears to be unimpaired.
dc.description.versionArticle
dc.identifier.citationNeurochemical Research
dc.identifier.citation12
dc.identifier.citation11
dc.identifier.issn03643190
dc.identifier.urihttp://hdl.handle.net/10019.1/14234
dc.subjectclonidine
dc.subjectdesipramine
dc.subjectisoprenaline
dc.subjectphentolamine
dc.subjectprotirelin
dc.subjectthyrotropin
dc.subjectadverse drug reaction
dc.subjectanimal experiment
dc.subjectcentral nervous system
dc.subjectnonhuman
dc.subjectoral drug administration
dc.subjectrat
dc.subjectAnimal
dc.subjectClonidine
dc.subjectDesipramine
dc.subjectDrug Interactions
dc.subjectIsoproterenol
dc.subjectMale
dc.subjectPhentolamine
dc.subjectProtirelin
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.subjectReceptors, Adrenergic
dc.subjectSupport, Non-U.S. Gov't
dc.subjectThyrotropin
dc.titleEffect of chronic desipramine treatment on neurotransmitter-thyrotropin releasing hormone - thyrotropin interactions in the rat
dc.typeArticle
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