Interaction of verapamil hydrochloride and atropine sulphate on histamine-induced bronchoconstriction

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dc.contributor.authorKrivoy N.
dc.contributor.authorBrandt H.D.
dc.contributor.authorBunn A.E.
dc.date.accessioned2011-05-15T15:57:34Z
dc.date.available2011-05-15T15:57:34Z
dc.date.issued1985
dc.description.abstractSubmaximal histamie dose-response curves were obtained on 34 dogs divided into six groups. These groups were: A (n = 6) untreated; B (n = 6) after atropine (1 mg/kg); C (n = 5) after verapamil inhalation (10 mg total dose); D (n = 5) after verapamil inhalation (100 mg total dose); E and F (n = 6) as for C and D but pre-treated with atropine (1 mg/kg). Total lung resistance (Rl) was measured in each case at increasing delivered concentrations of inhaled histamine and expressed as a ratio of baseline valve. For each group a composite mean curve was obtained and the maximal recorded responses (mean maximal resistance ratios) for the various groups were compared. It appears that the combination of verapamil inhalation (low dose) and atropine reduced the anticholinergic effect of atropine causing marked bronchoconstriction. This unexpected result depends on the verapamil dose since it was not present at the higher dose (group F).
dc.description.versionArticle
dc.identifier.citationRespiration
dc.identifier.citation47
dc.identifier.citation3
dc.identifier.issn257931
dc.identifier.urihttp://hdl.handle.net/10019.1/10472
dc.subjectatropine
dc.subjectcalcium channel blocking agent
dc.subjecthistamine
dc.subjectverapamil
dc.subjectanimal experiment
dc.subjectbreathing mechanics
dc.subjectbronchospasm
dc.subjectbronchus hyperreactivity
dc.subjectdog
dc.subjectdose response
dc.subjectdrug comparison
dc.subjectdrug interaction
dc.subjectdrug response
dc.subjectdrug therapy
dc.subjectinhalational drug administration
dc.subjectlung resistance
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrespiratory system
dc.subjecttherapy
dc.subjectAirway Resistance
dc.subjectAnimal
dc.subjectAtropine
dc.subjectBronchial Diseases
dc.subjectConstriction, Pathologic
dc.subjectDogs
dc.subjectDose-Response Relationship, Drug
dc.subjectDrug Interactions
dc.subjectFemale
dc.subjectHistamine
dc.subjectMale
dc.subjectSupport, Non-U.S. Gov't
dc.subjectVerapamil
dc.titleInteraction of verapamil hydrochloride and atropine sulphate on histamine-induced bronchoconstriction
dc.typeArticle
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