Are Polymorphic Markers within the α-1-Antitrypsin Gene Associated with Risk of Human Immunodeficiency Virus Disease?

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dc.contributor.authorHayes V.M.
dc.contributor.authorGardiner-Garden M.
dc.date.accessioned2011-05-15T16:03:34Z
dc.date.available2011-05-15T16:03:34Z
dc.date.issued2003
dc.description.abstractWe sought to determine whether variants of the human α-1-antitrypsin (AAT) gene, also known as "PI," or "SERPINA1," are associated with human immunodeficiency virus (HIV) infection in 2 African-based populations from HIV-pandemic sub-Saharan Africa. Eleven commonly occurring African-associated polymorphic markers in the coding and intronic regions of the AAT gene were analyzed via denaturing gradient gel electrophoresis. A significant association between HIV-1 infection and the presence of an allelic variant was observed in the case of the M2 and A332A haplotypes, thus presenting AAT as a potentially novel HIV-1 susceptibility locus.
dc.description.versionArticle
dc.identifier.citationJournal of Infectious Diseases
dc.identifier.citation188
dc.identifier.citation8
dc.identifier.issn221899
dc.identifier.other10.1086/378641
dc.identifier.urihttp://hdl.handle.net/10019.1/12678
dc.subjectalpha 1 antitrypsin
dc.subjectgene product
dc.subjectprotein pi
dc.subjectserpin a1
dc.subjectunclassified drug
dc.subjectaat gene
dc.subjectadult
dc.subjectAfrica
dc.subjectallelism
dc.subjectarticle
dc.subjectcoding
dc.subjectcontrolled study
dc.subjectdenaturing gradient gel electrophoresis
dc.subjectdisease marker
dc.subjectfemale
dc.subjectgene locus
dc.subjectgenetic analysis
dc.subjectgenetic association
dc.subjectgenetic marker
dc.subjectgenetic polymorphism
dc.subjectgenetic susceptibility
dc.subjectgenetic variability
dc.subjecthaplotype
dc.subjecthuman
dc.subjectHuman immunodeficiency virus
dc.subjectintron
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectnucleotide sequence
dc.subjectpopulation distribution
dc.subjectpopulation genetics
dc.subjectpriority journal
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAfrica South of the Sahara
dc.subjectAfrican Continental Ancestry Group
dc.subjectalpha 1-Antitrypsin
dc.subjectAsian Continental Ancestry Group
dc.subjectElectrophoresis, Polyacrylamide Gel
dc.subjectEuropean Continental Ancestry Group
dc.subjectFemale
dc.subjectGene Frequency
dc.subjectGenetic Markers
dc.subjectGenetic Predisposition to Disease
dc.subjectHaplotypes
dc.subjectHIV Infections
dc.subjectHIV Seronegativity
dc.subjectHIV-1
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPolymorphism, Genetic
dc.subjectVariation (Genetics)
dc.titleAre Polymorphic Markers within the α-1-Antitrypsin Gene Associated with Risk of Human Immunodeficiency Virus Disease?
dc.typeArticle
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