The effect of intrahippocampal injection of kainic acid on corticosterone release in rats

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dc.contributor.authorDaniels W.M.U.
dc.contributor.authorJaffer A.
dc.contributor.authorEngelbrecht A.H.
dc.contributor.authorRussell V.A.
dc.contributor.authorTaljaard J.J.F.
dc.date.accessioned2011-05-15T16:17:27Z
dc.date.available2011-05-15T16:17:27Z
dc.date.issued1990
dc.description.abstractThe aim of the present study was to investigate whether the hippocampus exerts a modulatory effect on the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Kainic acid was stereotaxically injected into the CA1 pyramidal cell layer of the dorsal hippocampus, causing histological and behavioural changes typical of kainic acid toxicity. The CA3 pyramidal cells of the dorsal hippocampus were selectively lesioned. Rats treated with kainic acid were hyperactive, executed clockwise rotatory movements and displayed epileptic seizures. The acute excitatory effect of kainic acid on glutamatergic receptors in the hippocampus resulted in an elevation in plasma corticosterone levels, suggesting a stimulation of HPA axis activity. Direct or indirect stimulation of the CA1 pyramidal cells of the dorsal hippocampus appeared to have caused the increase in corticosterone secretion.
dc.description.versionArticle
dc.identifier.citationNeurochemical Research
dc.identifier.citation15
dc.identifier.citation5
dc.identifier.issn03643190
dc.identifier.other10.1007/BF00966206
dc.identifier.urihttp://hdl.handle.net/10019.1/14226
dc.subjectcorticosterone
dc.subjectkainic acid
dc.subjectanimal experiment
dc.subjectarticle
dc.subjecthippocampus
dc.subjecthistology
dc.subjectmammal
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectAdrenal Glands
dc.subjectAnimal
dc.subjectBehavior, Animal
dc.subjectCircadian Rhythm
dc.subjectCorticosterone
dc.subjectHippocampus
dc.subjectHypothalamus
dc.subjectKainic Acid
dc.subjectKinetics
dc.subjectMale
dc.subjectMotor Activity
dc.subjectPituitary Gland
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.subjectReceptors, Glutamate
dc.subjectReceptors, Neurotransmitter
dc.subjectSupport, Non-U.S. Gov't
dc.subjectAnimalia
dc.subjectMammalia
dc.titleThe effect of intrahippocampal injection of kainic acid on corticosterone release in rats
dc.typeArticle
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