Necrotizing enterocolitis in infants born to women with severe early preeclampsia and absent end-diastolic umbilical artery Doppler flow velocity waveforms

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dc.contributor.authorKirsten G.F.
dc.contributor.authorVan Netta Z.
dc.contributor.authorSmith M.
dc.contributor.authorOdendaal H.
dc.date.accessioned2011-05-15T16:15:22Z
dc.date.available2011-05-15T16:15:22Z
dc.date.issued1999
dc.description.abstractThe aim of this study was to determine the prevalence of necrotizing enterocolitis (NEC) in infants born to a homogeneous group of women with severe preeclampsia before 34 weeks' gestation and who had absent end- diastolic umbilical artery Doppler flow (AEDF) or normal umbilical Doppler flow velocities (NUFV). A total of 242 infants were entered into the study. The mean birth weight was 1260.5 g (SD = 339) and the mean gestational age 30.5 weeks (SD = 2.0). Sixty-eight (28%) infants had AEDF, 43 (18%) had umbilical artery Doppler flow velocities between the 95th and 99th percentile, and 131 (54%) had NUFV. Forty-one (18%) infants developed NEC, of whom 20 (8%) developed definite and advanced NEC (grade 2 and 3). Of these, 16(80%) had grade 2 and 4(20%) had grade 3. Twenty-one (8%) infants developed suspected NEC (grade 1). The mean onset of grade 1 NEC (7.2 days) occurred significantly earlier than in those with grades 2 and 3 NEC (18.7 and 23.3 days, respectively). Of the 21 infants with grade 1 NEC, 10 (48%) had AEDF and 9 (43%) had NUFV. None of the infants with grades 2 or 3 NEC had AEDF. We conclude that although chronically hypoxemic fetuses born to women with severe early onset preeclampsia and AEDF respond by redistributing blood flow to vital organs and away from the gut; the intestinal compromise is of insufficient magnitude to induce intestinal necrosis or NEC. Enteral feeding, however, should be introduced cautiously in infants with AEDF, as so-called suspected NEC developed significantly more often in these infants.
dc.description.versionArticle
dc.identifier.citationAmerican Journal of Perinatology
dc.identifier.citation16
dc.identifier.citation6
dc.identifier.issn07351631
dc.identifier.urihttp://hdl.handle.net/10019.1/13304
dc.subjectadult
dc.subjectarticle
dc.subjectbirth weight
dc.subjectclinical article
dc.subjectdisease severity
dc.subjectdoppler flowmetry
dc.subjectenteric feeding
dc.subjectfemale
dc.subjectflow rate
dc.subjectgestational age
dc.subjecthuman
dc.subjecthypoxemia
dc.subjectinfant
dc.subjectintestine necrosis
dc.subjectnecrotizing enterocolitis
dc.subjectonset age
dc.subjectpreeclampsia
dc.subjectprevalence
dc.subjectpriority journal
dc.subjectumbilical artery
dc.subjectBlood Flow Velocity
dc.subjectDiastole
dc.subjectEnterocolitis, Necrotizing
dc.subjectFemale
dc.subjectFetal Hypoxia
dc.subjectHumans
dc.subjectInfant, Newborn
dc.subjectPre-Eclampsia
dc.subjectPregnancy
dc.subjectUltrasonography, Doppler
dc.subjectUltrasonography, Prenatal
dc.subjectUmbilical Arteries
dc.titleNecrotizing enterocolitis in infants born to women with severe early preeclampsia and absent end-diastolic umbilical artery Doppler flow velocity waveforms
dc.typeArticle
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