Tracking genome organization in rodents by Zoo-FISH

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dc.contributor.authorGraphodatsky A.S.
dc.contributor.authorYang F.
dc.contributor.authorDobigny G.
dc.contributor.authorRomanenko S.A.
dc.contributor.authorBiltueva L.S.
dc.contributor.authorPerelman P.L.
dc.contributor.authorBeklemisheva V.R.
dc.contributor.authorAlkalaeva E.Z.
dc.contributor.authorSerdukova N.A.
dc.contributor.authorFerguson-Smith M.A.
dc.contributor.authorMurphy W.J.
dc.contributor.authorRobinson T.J.
dc.date.accessioned2011-05-15T15:59:03Z
dc.date.available2011-05-15T15:59:03Z
dc.date.issued2008
dc.description.abstractThe number of rodent species examined by modern comparative genomic approaches, particularly chromosome painting, is limited. The use of human whole-chromosome painting probes to detect regions of homology in the karyotypes of the rodent index species, the mouse and rat, has been hindered by the highly rearranged nature of their genomes. In contrast, recent studies have demonstrated that non-murid rodents display more conserved genomes, underscoring their suitability for comparative genomic and higher-order systematic studies. Here we provide the first comparative chromosome maps between human and representative rodents of three major rodent lineages Castoridae, Pedetidae and Dipodidae. A comprehensive analysis of these data and those published for Sciuridae show (1) that Castoridae, Pedetidae and Dipodidae form a monophyletic group, and (2) that the European beaver Castor fiber (Castoridae) and the birch mouse Sicista betulina (Dipodidae) are sister species to the exclusion of the springhare Pedetes capensis (Pedetidae), thus resolving an enduring trifurcation in rodent higher-level systematics. Our results together with published data on the Sciuridae allow the formulation of a putative rodent ancestral karyotype (2n=50) that is thought to comprise the following 26 human chromosomal segments and/or segmental associations: HSA1pq, 1q/10p, 2pq, 2q, 3a, 3b/19p, 3c/21, 4b, 5, 6, 7a, 7b/16p, 8p/4a/8p, 8q, 9/11, 10q, 12a/22a, 12b/22b, 13, 14/15, 16q/19q, 17, 18, 20, X and Y. These findings provide insights into the likely composition of the ancestral rodent karyotype and an improved understanding of placental genome evolution. © 2008 Springer.
dc.description.versionArticle
dc.identifier.citationChromosome Research
dc.identifier.citation16
dc.identifier.citation2
dc.identifier.issn9673849
dc.identifier.other10.1007/s10577-007-1191-5
dc.identifier.urihttp://hdl.handle.net/10019.1/10980
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectarticle
dc.subjectchromosome analysis
dc.subjectchromosome band
dc.subjectchromosome identification
dc.subjectchromosome map
dc.subjectchromosome painting
dc.subjectchromosome structure
dc.subjectcontrolled study
dc.subjectcytogenetics
dc.subjectfemale
dc.subjectfluorescence in situ hybridization
dc.subjectgenome analysis
dc.subjectkaryotype
dc.subjectmale
dc.subjectmetaphase
dc.subjectmouse
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrodent
dc.subjectAnimals
dc.subjectChromosome Banding
dc.subjectDNA Probes
dc.subjectFemale
dc.subjectGenome
dc.subjectHumans
dc.subjectIn Situ Hybridization, Fluorescence
dc.subjectMale
dc.subjectMice
dc.subjectPhylogeny
dc.subjectRabbits
dc.subjectRats
dc.subjectRodentia
dc.subjectSciuridae
dc.subjectCastor fiber
dc.subjectCastoridae
dc.subjectDipodidae
dc.subjectMuridae
dc.subjectPedetes capensis
dc.subjectPedetidae
dc.subjectRattus
dc.subjectRodentia
dc.subjectSciuridae
dc.subjectSicista betulina
dc.titleTracking genome organization in rodents by Zoo-FISH
dc.typeArticle
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