Lack of effect of chronic desipramine treatment on dopaminergic activity in the nucleus accumbens of the rat

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dc.contributor.authorReyneke L.
dc.contributor.authorAllin R.
dc.contributor.authorRussell V.A.
dc.contributor.authorTaljaard J.J.F.
dc.date.accessioned2011-05-15T16:17:28Z
dc.date.available2011-05-15T16:17:28Z
dc.date.issued1989
dc.description.abstractThe binding of [3H]SCH 23390 to dopamine (DA) D1-receptors was measured in the nucleus accumbens of rats treated chronically with desipramine for 14 days. DA D1- and D2-receptor binding using [3H]SCH 23390 and [3H]spiperone, respectively as ligands, was determined in rats treated for 28 days. Neither B(max) nor K(d) values were influenced by chronic desipramine treatment. In addition, chronic desipramine treatment (28 days) did not influence the dose dependent, quinpirole (10 - 1000 nM)-mediated inhibition of the electrically stimulated release of [3H]DA and [14C]ACh from nucleus accumbens sclices or the dose dependent increase in [3H]DA release and decrease in [14C]ACh release in the presence of 1 and 10 μM nomifensine. Therefore, our results suggest that the effect of chronic antidepressant treatment cannot be attributed to changes in either DA D1- or D2-receptor binding or DA D2-receptor function in the nucleus accumbens.
dc.description.versionArticle
dc.identifier.citationNeurochemical Research
dc.identifier.citation14
dc.identifier.citation7
dc.identifier.issn03643190
dc.identifier.urihttp://hdl.handle.net/10019.1/14231
dc.subjectdesipramine
dc.subjectdopamine 1 receptor
dc.subjectdopamine 2 receptor
dc.subjectnomifensine
dc.subjectradioisotope
dc.subjectacetylcholine release
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectdopaminergic system
dc.subjectmale
dc.subjectnonhuman
dc.subjectnucleus accumbens
dc.subjectoral drug administration
dc.subjectpriority journal
dc.subjectrat
dc.subjectreceptor binding
dc.subjectAcetylcholine
dc.subjectAnimal
dc.subjectBenzazepines
dc.subjectDesipramine
dc.subjectDopamine
dc.subjectDopamine Agents
dc.subjectDopamine Antagonists
dc.subjectElectric Stimulation
dc.subjectErgolines
dc.subjectMale
dc.subjectNomifensine
dc.subjectNucleus Accumbens
dc.subjectQuinpirole
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.subjectReceptors, Dopamine
dc.subjectReceptors, Dopamine D1
dc.subjectReceptors, Dopamine D2
dc.subjectSch-23390
dc.subjectSeptal Nuclei
dc.subjectSpiperone
dc.subjectSupport, Non-U.S. Gov't
dc.titleLack of effect of chronic desipramine treatment on dopaminergic activity in the nucleus accumbens of the rat
dc.typeArticle
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