Digital papular calcific elastosis: A histopathological, histochemical and ultrastructural study of 20 patients

Simple item page
dc.contributor.authorJordaan H.F.
dc.contributor.authorRossouw D.J.
dc.date.accessioned2011-05-15T16:16:57Z
dc.date.available2011-05-15T16:16:57Z
dc.date.issued1990
dc.description.abstractIn 1960, 5 patients were reported with a condition termed 'degenerative collagenous plaques of the hands'. Ultraviolet light and chronic pressure seem to be the inciting factors. Clinically, it is characterized by keratotic, translucent papules, in linear array, on the radial border of the hands. Histology shows hyperkeratosis and dermal elastosis. The current study documented the histopathological, histochemical and ultrastructural features of 20 patients with this condition and considered the differential diagnoses. The findings were in accordance with those of previous studies, bu peculiar, basophilic elastotic masses (BEMs), were a prominent finding. Ultrastructurally, elastic tissue appeared in the form of degenerated non-fragmented and fragmented elastic fibres, degenerated fibres showing foci of increased density, with or without a fibrillar component and as amorphous, structureless material. BEMs arose almost exclusively from degenerated elastic tissue and contained calcium. Disintegrated collagen may be incorporated in the amorphous material and, subsequently, form a minor part of BEMs. Solar elastosis, and its variants, show some similarity to degenerative collagenous plaques of the hands, but lack the constant presence of these calcified angular elastotic masses. BEMs show resemblance to elastic globes, and elastotic bodies found in elastotic nodules of the anthelix and cartilage-hair hypoplasia. In the clinical setting of 'degenerative collagenous plaques of the hands', BEMs seem to be unique and due to their extensive presence serve as a non-specific marker for this condition. Digital papular calcific elastosis therefore seems to be more appropriate nomenclature.
dc.description.versionArticle
dc.identifier.citationJournal of Cutaneous Pathology
dc.identifier.citation17
dc.identifier.citation6
dc.identifier.issn03036987
dc.identifier.other10.1111/j.1600-0560.1990.tb00113.x
dc.identifier.urihttp://hdl.handle.net/10019.1/14008
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectclinical article
dc.subjectelastosis
dc.subjectfemale
dc.subjectfinger
dc.subjecthistochemistry
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectmale
dc.subjectpapule
dc.subjectpriority journal
dc.subjectskin calcification
dc.subjectultrastructure
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectCalcinosis
dc.subjectCollagen
dc.subjectElastic Tissue
dc.subjectFemale
dc.subjectHand Dermatoses
dc.subjectHistocytochemistry
dc.subjectHuman
dc.subjectMale
dc.subjectMiddle Age
dc.subjectSkin
dc.titleDigital papular calcific elastosis: A histopathological, histochemical and ultrastructural study of 20 patients
dc.typeArticle
Files
Collections
Stellenbosch University - Scopus Tygerberg Hospital Publications