Earlier age of onset of Alzheimer's disease in patients with both the transferrin C2 and apolipoprotein e-ε4 alleles

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dc.contributor.authorVan Rensburg S.J.
dc.contributor.authorPotocnik F.C.V.
dc.contributor.authorDe Villiers J.N.P.
dc.contributor.authorKotze M.J.
dc.contributor.authorTaljaard J.J.F.
dc.date.accessioned2011-05-15T16:15:31Z
dc.date.available2011-05-15T16:15:31Z
dc.date.issued2000
dc.description.abstractThe etiology of Alzheimer's disease is now known to be multifactorial. The genetic factors transferrin C2 (TfC2) and apolipoprotein E ε4 (ApoE-ε4) have both been associated with Alzheimer's disease (AD). Transferrin is the carrier protein for iron in the blood, while ApoE is involved with the transport and redistribution of lipids. In the present study, the polymerase chain reaction (PCR) method was used to determine the frequency of both TfC2 and ApoE-ε4 in 27 AD patients, 9 vascular dementia (VaD) patients, and 27 controls. Patients were diagnosed according to the criteria as set out in the 4th edition of the Diagnostic and Statistical Manual of the American Psychiatric Association (DSM-IV). The frequency of the TfC2 allele for the AD patients was 24%, while for the VaD patients it was 12.5%, which was not significantly different from the controls at 13%. The frequency of ApoE-ε4 for the AD patients was 44%, for the VaD patients 22%, and controls 17%. Of the 27 AD patients, 8 had both TfC2 and ApoE-ε4. The age of onset of the disease in these 8 patients (51-67 years, mean 60.25) was significantly earlier (p < 0.02) than in the remaining AD patients (49-76 years, mean 66.9). None of the VaD patients had both the TfC2 and the ApoE-ε4 alleles.
dc.description.versionConference Paper
dc.identifier.citationAnnals of the New York Academy of Sciences
dc.identifier.citation903
dc.identifier.issn00778923
dc.identifier.urihttp://hdl.handle.net/10019.1/13372
dc.subjectapolipoprotein E4
dc.subjecttransferrin
dc.subjecttransferrin c2
dc.subjectunclassified drug
dc.subjectadult
dc.subjectaged
dc.subjectAlzheimer disease
dc.subjectclinical article
dc.subjectconference paper
dc.subjectcontrolled study
dc.subjectgene frequency
dc.subjectheredity
dc.subjecthuman
dc.subjectmultiinfarct dementia
dc.subjectonset age
dc.subjectpolymerase chain reaction
dc.subjectAge of Onset
dc.subjectAged
dc.subjectAlleles
dc.subjectAlzheimer Disease
dc.subjectApolipoprotein E4
dc.subjectApolipoproteins E
dc.subjectDementia, Vascular
dc.subjectDNA
dc.subjectHumans
dc.subjectMiddle Aged
dc.subjectPolymerase Chain Reaction
dc.subjectProtein Isoforms
dc.subjectReference Values
dc.subjectTransferrin
dc.titleEarlier age of onset of Alzheimer's disease in patients with both the transferrin C2 and apolipoprotein e-ε4 alleles
dc.typeConference Paper
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