Phasic craving for carbohydrate observed with citalopram

Simple item page
dc.contributor.authorBouwer C.D.
dc.contributor.authorHarvey B.H.
dc.date.accessioned2011-05-15T15:59:19Z
dc.date.available2011-05-15T15:59:19Z
dc.date.issued1996
dc.description.abstractThe serotonin selective reuptake inhibitors (SSRIs) have clinically and ancedotally been associated with nausea and weight loss as a side effect of their action. The tricyclic antidepressants have been linked to carbohydrate (CHO) craving and weight gain in patients with major depressive disorders. This side effect has been attributed to the strong anti-histaminergic actions of these agents and is recognized as a causal factor of non-compliance in a substantial percentage of patients. CHO craving is an important feature and complication of the treatment of depression and is often ignored. A total of 18 patients were treated with the SSRI citalopram in our mood disorder clinic. In eight cases there was a significant increase in CHO craving together with weight gain shortly after initiation of treatment. The craving for CHO took on a phasic presentation. These cases are presented, together with data on the change in mood and anxiety symptom rating scales. Our observations appear paradoxical, given that serotonin (5-HT) typically mediates a reduction in CHO intake and that citalopram displays potent and select 5-HT-enchancing actions. However, the receptor binding profile of citalopram may predict a risk for inducing this adverse event. These, together with serotonergic, dopaminergic, histaminergic and other possible mechanisms are discussed. A profound influence on patient acceptability was observed, suggesting that the impact on compliance needs to be considered.
dc.description.versionArticle
dc.identifier.citationInternational Clinical Psychopharmacology
dc.identifier.citation11
dc.identifier.citation4
dc.identifier.issn2681315
dc.identifier.urihttp://hdl.handle.net/10019.1/11115
dc.subjectcarbohydrate
dc.subjectcitalopram
dc.subjectfluoxetine
dc.subjectfluvoxamine
dc.subjectparoxetine
dc.subjectserotonin
dc.subjectserotonin uptake inhibitor
dc.subjectsertraline
dc.subjecttricyclic antidepressant agent
dc.subjectadult
dc.subjectarticle
dc.subjectclinical article
dc.subjectdepression
dc.subjectfemale
dc.subjecthuman
dc.subjectmale
dc.subjectnausea
dc.subjectpatient compliance
dc.subjectpriority journal
dc.subjectserotoninergic system
dc.subjectweight gain
dc.subjectAdolescent
dc.subjectAdult
dc.subjectBody Weight
dc.subjectCitalopram
dc.subjectDepressive Disorder
dc.subjectDietary Carbohydrates
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.titlePhasic craving for carbohydrate observed with citalopram
dc.typeArticle
Files
Collections
Stellenbosch University - Scopus Publications