Management of children exposed to multidrug-resistant Mycobacterium tuberculosis

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dc.contributor.authorSeddon J.A.
dc.contributor.authorGodfrey-Faussett P.
dc.contributor.authorHesseling A.C.
dc.contributor.authorGie R.P.
dc.contributor.authorBeyers N.
dc.contributor.authorSchaaf H.S.
dc.date.accessioned2012-06-06T08:02:29Z
dc.date.available2012-06-06T08:02:29Z
dc.date.issued2012
dc.description.abstractChildren exposed to multidrug-resistant (MDR) Mycobacterium tuberculosis are at risk of developing MDR tuberculosis. Where treatment is available, it is lengthy, expensive, and associated with poor adherence and notable morbidity and mortality. Preventive treatment effectively lowers the risk of disease progression for contacts of individuals with drug-susceptible tuberculosis, but this strategy is poorly studied for contacts of people with MDR tuberculosis. In this Review we discuss the management of child contacts of source cases with MDR tuberculosis. We pay particular attention to assessment, existing international guidelines, possible preventive treatments, rationales for different management strategies, and the interaction with and implications of HIV infection. © 2012 Elsevier Ltd.
dc.identifier.citationThe Lancet Infectious Diseases
dc.identifier.citation12
dc.identifier.citation6
dc.identifier.citation469
dc.identifier.citation479
dc.identifier.issn14733099
dc.identifier.otherdoi:10.1016/S1473-3099(11)70366-8
dc.identifier.urihttp://hdl.handle.net/10019.1/21328
dc.titleManagement of children exposed to multidrug-resistant Mycobacterium tuberculosis
dc.typeReview
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