Evidence that noradrenergic neuronsin the A1 and A2 nuclei are lesioned by low doses of 6-OHDA injected into the locus coeruleus

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dc.contributor.authorEngelbrecht A.H.
dc.contributor.authorRussell V.
dc.contributor.authorCarstens M.E.
dc.contributor.authorDe Villiers A.S.
dc.contributor.authorSearson A.
dc.contributor.authorJafer A.
dc.contributor.authorTaljaard J.J.F.
dc.date.accessioned2011-05-15T16:17:04Z
dc.date.available2011-05-15T16:17:04Z
dc.date.issued1994
dc.description.abstractIn order to determine the specificity of a lesion aimed at the locus coeruleus (LC), various doses of 6-hydroxydopamine (6-OHDA), a neurotoxin which selectively lesions catecholaminergic neurons, were bilaterally infused into the LC. The noradrenaline (NA) concentration in the frontal cortex, hippocampus, hypothalamus, LC, A1 and A2 nuclei decreased with increasing doses of 6-OHDA. A 1 μg dose of 6-OHDA injected bilaterally into the LC caused maximal depletion of the NA concentration in the frontal cortex, hippocampus and A1 and A2 nuclei. A dose of 2 μg 6-OHDA caused further depletion of the NA content of the hypothalamus and LC. These findings suggest that A1 and A2 neurons which project to the hypothalamus may have been lesioned or that the noradrenergic projection from the LC to the hypothalamus may be greater than was previously suspected. Alternatively, leakage of 6-OHDA into the cerebrospinal fluid may have occurred at the higher doses, thus directly exposing the hypothalamus to the toxic effects of 6-OHDA.
dc.description.versionArticle
dc.identifier.citationJournal of Neuroscience Methods
dc.identifier.citation52
dc.identifier.citation1
dc.identifier.issn01650270
dc.identifier.other10.1016/0165-0270(94)90056-6
dc.identifier.urihttp://hdl.handle.net/10019.1/14059
dc.subjectnoradrenalin
dc.subjectoxidopamine
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectbrain injury
dc.subjectcontrolled study
dc.subjectfrontal cortex
dc.subjecthippocampus
dc.subjecthypothalamus
dc.subjectlocus ceruleus
dc.subjectmale
dc.subjectnonhuman
dc.subjectnoradrenalin brain level
dc.subjectnoradrenergic nerve
dc.subjectpriority journal
dc.subjectrat
dc.subjectanimal
dc.subjectdose response
dc.subjectdrug effect
dc.subjectfrontal lobe
dc.subjectinjection
dc.subjectmetabolism
dc.subjectnerve cell
dc.subjectosmolarity
dc.subjectphysiology
dc.subjectrat strain
dc.subjectsynaptic transmission
dc.subjectAnimal
dc.subjectDose-Response Relationship, Drug
dc.subjectFrontal Lobe
dc.subjectHippocampus
dc.subjectHypothalamus
dc.subjectInjections
dc.subjectLocus Coeruleus
dc.subjectMale
dc.subjectNeurons
dc.subjectNorepinephrine
dc.subjectOsmolar Concentration
dc.subjectOxidopamine
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSupport, Non-U.S. Gov't
dc.subjectSynaptic Transmission
dc.titleEvidence that noradrenergic neuronsin the A1 and A2 nuclei are lesioned by low doses of 6-OHDA injected into the locus coeruleus
dc.typeArticle
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