Iron status in children with recurrent episodes of tumefactive cerebral demyelination

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dc.contributor.authorVan Toorn R.
dc.contributor.authorSchoeman J.F.
dc.contributor.authorSolomons R.
dc.contributor.authorRensburg M.A.
dc.contributor.authorVan Rensburg S.J.
dc.date.accessioned2011-05-15T16:16:52Z
dc.date.available2011-05-15T16:16:52Z
dc.date.issued2010
dc.description.abstractIron is a vital element in the multifactorial initiation of myelination. It is required for cholesterol and lipid biosynthesis, both key components of myelin. Iron also plays an important role in energy production by mitochondrial oxidative metabolism which occurs in myelin-producing oligodentrocytes at a higher rate than in any other cell. Iron deficiency can, therefore, result in decreased oligodendrocyte survival and defective myelination. This led us to investigate iron status in 2 consecutive children with multiple sclerosis who presented with recurrent episodes of tumefactive demyelination. Testing revealed nonanemic iron deficiency in both patients. Discontinuation of iron supplementation in both children resulted in recurrent decreased iron parameters which can indicate mutations in proteins responsible for regulation of iron uptake. Further studies are warranted to explore the association of low iron in children presenting with recurrent episodes of tumefactive demyelination. © The Author(s) 2010.
dc.description.versionArticle
dc.identifier.citationJournal of Child Neurology
dc.identifier.citation25
dc.identifier.citation11
dc.identifier.issn08830738
dc.identifier.other10.1177/0883073810366179
dc.identifier.urihttp://hdl.handle.net/10019.1/13973
dc.subjectiron
dc.subjectmethylprednisolone
dc.subjectprednisone
dc.subjectanthropometry
dc.subjectarticle
dc.subjectcase report
dc.subjectchild
dc.subjectdemyelinating disease
dc.subjectdisease association
dc.subjectdrug dose reduction
dc.subjectdrug withdrawal
dc.subjecthuman
dc.subjectiron deficiency
dc.subjectiron therapy
dc.subjectiron transport
dc.subjectlumbar puncture
dc.subjectmale
dc.subjectmotor performance
dc.subjectmultiple sclerosis
dc.subjectneuroimaging
dc.subjectneurologic examination
dc.subjectnuclear magnetic resonance imaging
dc.subjectoptic neuritis
dc.subjectpreschool child
dc.subjectpriority journal
dc.subjectthorax radiography
dc.subjecttumefactive demyelination
dc.subjectCerebral Cortex
dc.subjectChild, Preschool
dc.subjectDemyelinating Diseases
dc.subjectHemoglobins
dc.subjectHumans
dc.subjectInfant
dc.subjectIron
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectRecurrence
dc.titleIron status in children with recurrent episodes of tumefactive cerebral demyelination
dc.typeArticle
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