Complex evolution of X and Y autosomal translocations in the giant mole-rat, Cryptomys mechowi (Bathyergidae)

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dc.contributor.authorDeuve J.L.
dc.contributor.authorBennett N.C.
dc.contributor.authorO'Brien P.C.M.
dc.contributor.authorFerguson-Smith M.A.
dc.contributor.authorFaulkes C.G.
dc.contributor.authorBritton-Davidian J.
dc.contributor.authorRobinson T.J.
dc.date.accessioned2011-05-15T15:59:04Z
dc.date.available2011-05-15T15:59:04Z
dc.date.issued2006
dc.description.abstractCross-species chromosome painting was used to determine homologous chromosomal regions between two species of mole-rat, the naked mole-rat, Heterocephalus glaber (2n = 60), and the giant mole-rat, Cryptomys mechowi (2n = 40), using flow-sorted painting probes representative of all but two of the H. glaber chromosomal complement. In total 43 homologous regions were identified in the C. mechowi genome. Eight H. glaber chromosomes are retained in toto in C. mechowi, and 13 produce two or more signals in this species. The most striking difference in the karyotypes of the two taxa concerns their sex chromosomes. The H. glaber painting probes identified a complex series of translocations that involved the fractionation of four autosomes and the subsequent translocation of segments to the sex chromosomes and to autosomal partners in the C. mechowi genome. An intercalary heterochromatic block (IHB) was detected in sex chromosomes of C. mechowi at the boundary with the translocated autosomal segment. We discuss the likely sequence of evolutionary events that has led to the contemporary composition of the C. mechowi sex chromosomes, and consider these in the light of prevailing views on the genesis of sex chromosomes in mammals. © Springer 2006.
dc.description.versionArticle
dc.identifier.citationChromosome Research
dc.identifier.citation14
dc.identifier.citation6
dc.identifier.issn9673849
dc.identifier.other10.1007/s10577-006-1080-3
dc.identifier.urihttp://hdl.handle.net/10019.1/10986
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectarticle
dc.subjectautosome
dc.subjectchromosome G band
dc.subjectchromosome painting
dc.subjectcontrolled study
dc.subjectevolution
dc.subjectfemale
dc.subjectgene dosage
dc.subjectheterochromatin
dc.subjectin situ hybridization
dc.subjectkaryotype
dc.subjectmale
dc.subjectmetaphase
dc.subjectmole rat
dc.subjectnonhuman
dc.subjectpolymerase chain reaction
dc.subjectpriority journal
dc.subjectrat
dc.subjectX chromosome
dc.subjectY chromosome
dc.subjectAnimals
dc.subjectChromosome Painting
dc.subjectEvolution, Molecular
dc.subjectFemale
dc.subjectKaryotyping
dc.subjectMole Rats
dc.subjectRats
dc.subjectTranslocation, Genetic
dc.subjectX Chromosome
dc.subjectY Chromosome
dc.subjectBathyergidae
dc.subjectCoetomys mechowi
dc.subjectHeterocephalus glaber
dc.subjectMammalia
dc.subjectSpalax giganteus
dc.titleComplex evolution of X and Y autosomal translocations in the giant mole-rat, Cryptomys mechowi (Bathyergidae)
dc.typeArticle
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