Mycobacterial genotype is associated with disease phenotype in children

Simple item page
dc.contributor.authorHesseling A.C.
dc.contributor.authorMarais B.J.
dc.contributor.authorKirchner H.L.
dc.contributor.authorMandalakas A.M.
dc.contributor.authorBrittle W.
dc.contributor.authorVictor T.C.
dc.contributor.authorWarren R.M.
dc.contributor.authorSchaaf H.S.
dc.date.accessioned2011-05-15T15:53:45Z
dc.date.available2011-05-15T15:53:45Z
dc.date.issued2010
dc.description.abstractOBJECTIVE: To investigate the association between mycobacterial genotype and disease phenotype in children. METHODS: We describe hospitalised children diagnosed with culture-confirmed tuberculosis (TB) in South Africa, a high TB burden setting. Disease phenotype was classi-fied as intrathoracic or extrathoracic based on mycobacterial culture site. Mycobacterial genotyping was completed using spoligotyping. RESULTS: We analysed 421 isolates from 392 children (median age 2 years, range 0.1-12). Intrathoracic disease was present in 294 (75%) children and extrathoracic disease in 98 (25%). The Beijing genotype was the most prevalent (32.9%), followed by the Latin American Mediterranean (LAM, 28.8%), and S genotypes (6.4%). Age was significantly associated with genotype. Children with the Beijing (OR = 2.36, 95%CI 1.21-4.60) and S genotypes (OR = 3.47, 95%CI 1.26-9.56) were more likely to have extrathoracic disease compared to children infected with the LAM genotype, in analyses adjusted for age and drug resistance. CONCLUSIONS: TB genotype and disease phenotype in children were associated. Beijing and S genotypes were more frequently cultured from extrathoracic cultures, indicating potential improved ability to disseminate. Strain-related phenotypes could explain different disease spectra in geographic settings where certain strains are successful. Studies of mycobacterial human interaction should consider host immune responses, clinical and epidemiological factors. © 2010 The Union.
dc.description.versionArticle
dc.identifier.citationInternational Journal of Tuberculosis and Lung Disease
dc.identifier.citation14
dc.identifier.citation10
dc.identifier.issn10273719
dc.identifier.urihttp://hdl.handle.net/10019.1/8791
dc.titleMycobacterial genotype is associated with disease phenotype in children
dc.typeArticle
Files
Collections
Stellenbosch University - Scopus Publications