Plasma vitamin levels in patients on prolonged total parenteral nutrition

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dc.contributor.authorLabadarios D.
dc.contributor.authorO'Keefe S.J.D.
dc.contributor.authorDicker J.
dc.contributor.authorVan Stuijvenberg L.
dc.contributor.authorVisser L.
dc.contributor.authorLouw M.E.J.
dc.contributor.authorShephard G.S.
dc.date.accessioned2011-05-15T16:17:07Z
dc.date.available2011-05-15T16:17:07Z
dc.date.issued1988
dc.description.abstractVitamins are essential in total parenteral nutrition (TPN), their importance being highlighted by repeated past documentation of various vitamin deficiencies particularly in patients on long-term parenteral nutrition therapy. This study evaluated the efficacy of water- (Soluvit) and fat-soluble (Vitalipid) vitamin supplementation in patients receiving total parenteral nutrition using the three in one 3-liter bag system. All patients received water-soluble vitamin supplements daily. Fat-soluble vitamin supplements were administered on a daily or twice weekly basis. Twenty-two patients were studied. In seven of the 22 patients vitamin status was assessed on more than one occasion during TPN support, thus bringing the total number of observations to 30. The mean duration of TPN support was 35 days. Eight of the observations were made during less than 10 days, three between 11-19 days, 15 between 20-60 days, and four during more than 60 days of TPN support. Biochemical deficiency as judged by subnormal enzyme activity or vitamin levels were present in 10% of the patients for thiamin, 3% for riboflavin, and 6% for nicotinic acid. By contrast 83% of the patients had low plasma vitamin C and B6 levels. Low plasma vitamin A and E levels were also present in 43 and 40% of the patients, respectively. According to the plasma concentrations of the vitamins studied it would appear that the commercial vitamin preparations used in this study are inadequate in maintaining optimal vitamin status. Our results indicate that on the basis of the low plasma concentrations found, vitamin deficiencies can occur in patients when commercial preparations are used that do not comply with the current guidelines of maintenance requirements. We further recommend that vitamin status assessment, when possible, is incorporated in the overall patient management.
dc.description.versionArticle
dc.identifier.citationJournal of Parenteral and Enteral Nutrition
dc.identifier.citation12
dc.identifier.citation2
dc.identifier.issn01486071
dc.identifier.urihttp://hdl.handle.net/10019.1/14076
dc.subjectvitamin
dc.subjectclinical article
dc.subjectfemale
dc.subjecthuman
dc.subjectmale
dc.subjecttotal parenteral nutrition
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectErythrocytes
dc.subjectFemale
dc.subjectHuman
dc.subjectMale
dc.subjectMiddle Age
dc.subjectParenteral Nutrition, Total
dc.subjectThiamine Pyrophosphate
dc.subjectTransketolase
dc.subjectVitamin E
dc.subjectVitamins
dc.titlePlasma vitamin levels in patients on prolonged total parenteral nutrition
dc.typeArticle
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