Childhood pseudotumor cerebri: Clinical and intracranial pressure response to acetazolamide and furosemide treatment in a case series

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dc.contributor.authorSchoeman J.F.
dc.date.accessioned2011-05-15T16:16:53Z
dc.date.available2011-05-15T16:16:53Z
dc.date.issued1994
dc.description.abstractThe purpose of this study was to investigate the efficacy of combined therapy with acetazolamide and furosemide in normalizing intracranial pressure in children with pseudotumor cerebri. The role of repeated lumbar cerebrospinal fluid pressure monitoring in evaluating the response to therapy is also demonstrated. Continuous 1-hour lumbar cerebrospinal fluid pressure monitoring was done in eight children with pseudotumor cerebri on admission and at weekly intervals until the baseline pressure had normalized. (One child had two episodes of pseudotumor cerebri). All patients were treated with oral acetazolamide and furosemide until papilledema had cleared. Raised intracranial pressure was present on admission in all nine episodes of pseudotumor cerebri. Six children had an increased baseline cerebrospinal fluid pressure, whereas raised intracranial pressure was diagnosed in three children on account of an abnormal pulse wave and/or pressure waves. The mean baseline pressure was significantly lower after the 1st week of treatment than on admission (P = .007) and normalized in all patients within 6 weeks of start of therapy. All children had a rapid clinical response. Combined therapy with acetazolamide and furosemide is an effective first-line method of treating raised intracranial pressure in children with pseudotumor cerebri. The good correlation found between the clinical response and normalization of baseline cerebrospinal fluid pressure suggests that clinical monitoring of treatment is adequate in most children with this condition.
dc.description.versionArticle
dc.identifier.citationJournal of Child Neurology
dc.identifier.citation9
dc.identifier.citation2
dc.identifier.issn08830738
dc.identifier.urihttp://hdl.handle.net/10019.1/13979
dc.subjectacetazolamide
dc.subjectcotrimoxazole
dc.subjectfurosemide
dc.subjectsulfamethoxazole
dc.subjecttrimethoprim
dc.subjectadolescent
dc.subjectarticle
dc.subjectbrain pseudotumor
dc.subjectcerebrospinal fluid pressure
dc.subjectchild
dc.subjectchildhood disease
dc.subjectclinical article
dc.subjectclinical trial
dc.subjectdrug mixture
dc.subjectfemale
dc.subjecthuman
dc.subjectinfant
dc.subjectintracranial hypertension
dc.subjectmale
dc.subjectoral drug administration
dc.subjectotitis media
dc.subjectpapilledema
dc.subjectpatient monitoring
dc.subjectpriority journal
dc.subjecturinary tract infection
dc.subjectAcetazolamide
dc.subjectAdministration, Oral
dc.subjectAdolescent
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectDose-Response Relationship, Drug
dc.subjectDrug Therapy, Combination
dc.subjectFemale
dc.subjectFurosemide
dc.subjectHuman
dc.subjectInfant
dc.subjectIntracranial Pressure
dc.subjectMale
dc.subjectPilot Projects
dc.subjectPseudotumor Cerebri
dc.titleChildhood pseudotumor cerebri: Clinical and intracranial pressure response to acetazolamide and furosemide treatment in a case series
dc.typeArticle
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