Mapping of the variegate porphyria (VP) gene: Contradictory evidence for linkage between VP and microsatellite markers at chromosome 14q32

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dc.contributor.authorWarnich L.
dc.contributor.authorMeissner P.N.
dc.contributor.authorHift R.J.
dc.contributor.authorLouw J.H.
dc.contributor.authorVan Heerden C.J.
dc.contributor.authorRetief A.E.
dc.date.accessioned2011-05-15T15:59:12Z
dc.date.available2011-05-15T15:59:12Z
dc.date.issued1996
dc.description.abstractThe gene for variegate porphyria (VP), an autosomal dominant disease with a high prevalence in South Africa, evidently due to a founder effect, was previously mapped to chromosome 14q32. In the current study this localization was evaluated by linkage and haplotype analyses using microsatellite markers spanning a region of more than 20 cM on chromosome 14q32. In many recent studies linkage disequilibrium between disease and marker loci has been utilized to map genes in founder populations, but we could not find any association between VP and the markers used in this study. Our data suggest that the allocation of VP to chromosome 14q32 may be incorrect.
dc.description.versionArticle
dc.identifier.citationHuman Genetics
dc.identifier.citation97
dc.identifier.citation5
dc.identifier.issn3406717
dc.identifier.other10.1007/s004390050118
dc.identifier.urihttp://hdl.handle.net/10019.1/11053
dc.subjectdna marker
dc.subjectsatellite dna
dc.subjectarticle
dc.subjectchromosome 14q
dc.subjectclinical article
dc.subjectgene mapping
dc.subjectgenetic linkage
dc.subjecthaplotype
dc.subjecthuman
dc.subjecthuman cell
dc.subjectporphyria variegata
dc.subjectpriority journal
dc.subjectChromosome Mapping
dc.subjectChromosomes, Human, Pair 14
dc.subjectDNA, Satellite
dc.subjectFamily
dc.subjectFemale
dc.subjectGenes, Dominant
dc.subjectGenetic Markers
dc.subjectGenotype
dc.subjectHumans
dc.subjectLinkage (Genetics)
dc.subjectMale
dc.subjectMicrosatellite Repeats
dc.subjectPorphyrias, Hepatic
dc.subjectPrevalence
dc.subjectSouth Africa
dc.titleMapping of the variegate porphyria (VP) gene: Contradictory evidence for linkage between VP and microsatellite markers at chromosome 14q32
dc.typeArticle
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