Contraceptive efficacy of 200μg R2323 and 10μg R2858

Simple item page
dc.contributor.authorRall H.J.S.
dc.date.accessioned2011-05-15T16:16:08Z
dc.date.available2011-05-15T16:16:08Z
dc.date.issued1981
dc.description.abstractInvestigation into the contraceptive efficacy of 200 μg R2323 (13-ethyl-17-hydroxy-18, 19-dinor-17α-pregna-4, 9, 11-trien-20-yn-3-one) and 10 μg R2858 (11β-methoxy-17α-ethinyl-oestradiol) as a combination pill, was carried out in a group of 86 healthy females of proven fertility during 667 cycles (mean 7.74 cycles). A total of 10 pregnancies occurred for a pregnancy rate of 19.5, computed by the Pearl formula, but only four were considered drug failures. Although side-effects were generally minimal, one case of cerebral thrombosis was reported. Only two women complained of menorrhagia and three developed amenorrhoea while on therapy. Papanicolaou smears were taken at two- to three-month intervals for a total of 161 smears and no malignant changes were recorded.
dc.identifier.citationClinical Trials Journal
dc.identifier.citation18
dc.identifier.citation6
dc.identifier.issn00099325
dc.identifier.urihttp://hdl.handle.net/10019.1/13650
dc.subjectcontraceptive agent
dc.subjectgestrinone
dc.subjectmoxestrol
dc.subjectadverse drug reaction
dc.subjectcontraception
dc.subjectmenorrhagia
dc.subjectmethoxyethinylestradiol
dc.subjectocclusive cerebrovascular disease
dc.subjectoral drug administration
dc.subjectpregnancy
dc.subjectprevention
dc.subjectsecondary amenorrhea
dc.titleContraceptive efficacy of 200μg R2323 and 10μg R2858
Files
Collections
Stellenbosch University - Scopus Tygerberg Hospital Publications