The effects of repeated intra-amygdala CRF injections on rat behavior and HPA axis function after stress

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dc.contributor.authorDaniels W.M.U.
dc.contributor.authorRichter L.
dc.contributor.authorStein D.J.
dc.date.accessioned2011-05-15T15:59:59Z
dc.date.available2011-05-15T15:59:59Z
dc.date.issued2004
dc.description.abstractPatients diagnosed with certain anxiety disorders or depression show symptoms of a dysregulated HPA-axis secondary to increased release of corticotropin releasing factor (CRF). Male Wistar rats were injected with CRF (100 ng/μL) in the basolateral amygdala (BLA) for 5 days. Measurement of behavior was performed on the elevated plus maze and open field test. Behavioral and neuroendocrine response to restraint stress was also evaluated. Chronic treatment of CRF resulted in a significant increase in grooming after restraint stress in the Open Field test. Basal plasma corticosterone concentrations were significantly lower in the CRF-injected rats. These animals also showed greater and longer increase in corticosterone levels following the restraint stress than controls, but had comparable ACTH responses to restraint stress. Our results indicate that chronic administration of CRF into the basolateral amygdala may promote stress-induced grooming behavior in rats. In addition the data suggests that increased CRF in the amygdala may contribute to the dysregulation of corticosterone secretion. These findings may have important implications for patients suffering from psychiatric illnesses such as posttraumatic stress disorder and depression that are characterized by abnormalities in cortisol release.
dc.description.versionConference Paper
dc.identifier.citationMetabolic Brain Disease
dc.identifier.citation19
dc.identifier.citation02-Jan
dc.identifier.issn8857490
dc.identifier.other10.1023/B:MEBR.0000027413.42946.61
dc.identifier.urihttp://hdl.handle.net/10019.1/11464
dc.subjectcorticotropin releasing factor
dc.subjectcorticosterone
dc.subjectcorticotropin
dc.subjectamygdaloid nucleus
dc.subjectanimal behavior
dc.subjectanimal experiment
dc.subjectanxiety disorder
dc.subjectbehavior
dc.subjectbrain dysfunction
dc.subjectconference paper
dc.subjectcontrolled study
dc.subjectcorticosterone blood level
dc.subjectcorticosterone release
dc.subjectdepression
dc.subjectgrooming
dc.subjecthydrocortisone release
dc.subjecthypothalamus hypophysis adrenal system
dc.subjectimmobilization stress
dc.subjectmale
dc.subjectnonhuman
dc.subjectopen field test
dc.subjectposttraumatic stress disorder
dc.subjectrat
dc.subjectstatistical significance
dc.subjectstress
dc.subjectanimal
dc.subjectarticle
dc.subjectblood
dc.subjectchemically induced disorder
dc.subjectdrug effect
dc.subjecthypophysis adrenal system
dc.subjecthypothalamus hypophysis system
dc.subjectmicroinjection
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectWistar rat
dc.subjectAnimalia
dc.subjectRattus norvegicus
dc.subjectAdrenocorticotropic Hormone
dc.subjectAmygdala
dc.subjectAnimals
dc.subjectBehavior, Animal
dc.subjectCorticosterone
dc.subjectCorticotropin-Releasing Hormone
dc.subjectHypothalamo-Hypophyseal System
dc.subjectMale
dc.subjectMicroinjections
dc.subjectPituitary-Adrenal System
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectStress Disorders, Post-Traumatic
dc.titleThe effects of repeated intra-amygdala CRF injections on rat behavior and HPA axis function after stress
dc.typeConference Paper
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