The effects of B-sitosterol (BSS) and B-sitosterol glucoside (BSSG) mixture on selected immune parameters of marathon runners: Inhibition of post marathon immune suppression and inflammation

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dc.contributor.authorBouic P.J.D.
dc.contributor.authorClark A.
dc.contributor.authorLamprecht J.
dc.contributor.authorFreestone M.
dc.contributor.authorPool E.J.
dc.contributor.authorLiebenberg R.W.
dc.contributor.authorKotze D.
dc.contributor.authorVan Jaarsveld P.P.
dc.date.accessioned2011-05-15T16:16:45Z
dc.date.available2011-05-15T16:16:45Z
dc.date.issued1999
dc.description.abstractA pilot study was undertaken to investigate the effects of the intake of capsules containing the plant sterols and sterolins (BSS:BSSG mixture) on selected immune parameters of volunteers participating in an ultra-marathon in Cape Town, South Africa. Those runners having received active capsules (n = 9) showed less neutrophilia, lymphopenia and leukocytosis when compared to their counterparts having received placebo capsules (n = 8): the placebo treated individuals showed significant increases in their total white blood cell numbers as well as in their neutrophils (p = 0.03 and 0.03 respectively). Furthermore, statistically significant increases within lymphocyte subsets were observed in the runners having received the active capsules: CD3+ cells increased (p = 0.02) as did CD4+ cells (p = 0.03). In parallel, the BSS:BSSG capsules decreased the plasma level of IL6 in the runners using the active capsules (p = 0.08) and significantly decreased the cortisol: DHEAs ratio (p = 0.03), suggesting that these volunteers had less of an inflammatory response and were less immune suppressed during the post-marathon recovery period. These findings justify further investigations into the use of the phytosterols to prevent the subtle immunosuppression associated with excessive physical stress.
dc.description.versionArticle
dc.identifier.citationInternational Journal of Sports Medicine
dc.identifier.citation20
dc.identifier.citation4
dc.identifier.issn01724622
dc.identifier.other10.1055/s-2007-971127
dc.identifier.urihttp://hdl.handle.net/10019.1/13919
dc.subjectcd3 antigen
dc.subjectcd4 antigen
dc.subjecthydrocortisone
dc.subjectinterleukin 6
dc.subjectphytosterol
dc.subjectprasterone
dc.subjectsitogluside
dc.subjectsitosterol
dc.subjectadult
dc.subjectantiinflammatory activity
dc.subjectarticle
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdouble blind procedure
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman experiment
dc.subjectimmune response
dc.subjectimmunomodulation
dc.subjectimmunosuppressive treatment
dc.subjectleukocyte count
dc.subjectleukocytosis
dc.subjectlymphocyte subpopulation
dc.subjectlymphocytopenia
dc.subjectmale
dc.subjectmarathon runner
dc.subjectneutrophilia
dc.subjectnormal human
dc.subjectphysical stress
dc.subjectrandomized controlled trial
dc.subjectSouth Africa
dc.subjectstatistical analysis
dc.subjectAdult
dc.subjectBlood Cell Count
dc.subjectDietary Supplements
dc.subjectExercise
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunosuppression
dc.subjectInflammation
dc.subjectLeukocytosis
dc.subjectLymphocyte Subsets
dc.subjectLymphopenia
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeutrophils
dc.subjectPhytosterols
dc.subjectSitosterols
dc.titleThe effects of B-sitosterol (BSS) and B-sitosterol glucoside (BSSG) mixture on selected immune parameters of marathon runners: Inhibition of post marathon immune suppression and inflammation
dc.typeArticle
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