Endoscopy findings in HIV-infected children from sub-Saharan Africa

Simple item page
dc.contributor.authorCooke M.L.
dc.contributor.authorGoddard E.A.
dc.contributor.authorBrown R.A.
dc.date.accessioned2011-05-15T16:02:03Z
dc.date.available2011-05-15T16:02:03Z
dc.date.issued2009
dc.description.abstractBackground: The causes of persistent gastro-intestinal symptoms in HIV-infected children from sub-Saharan Africa remain poorly documented. Methods: The clinical, radiological and endoscopic findings of all HIV-infected children who underwent upper GI endoscopy at Red Cross Children's Hospital, Cape Town, South Africa, from February 2003 to October 2005 were documented. Results: Twenty-six HIV-infected children underwent endoscopy; median age 1 year (range: 0.17-10.9 years). The majority had advanced HIV disease; 18 (69%) were WHO Stage 4; median CD4 10.7% (range: 1-39.8%). Presenting symptoms included persistent vomiting (18), dysphagia (4) and GIT bleed (6). Observational and histological findings showed poor correlation. Pathogens were identified in 10 children: cytomegalovirus infection in seven (two with cryptosporidium co-infection), Candida in two, Helicobacter pylori in one. Age and CD4 count were not associated with the pathogens. Endoscopy findings influenced clinical management in 21 (81%) cases. Conclusion: Upper-GI endoscopy identified a diverse spectrum of disease and provided information that would be clinically relevant to most HIV-infected children with upper gastro-intestinal symptoms. © The Author [2009]. Published by Oxford University Press. All rights reserved.
dc.description.versionArticle
dc.identifier.citationJournal of Tropical Pediatrics
dc.identifier.citation55
dc.identifier.citation4
dc.identifier.issn1426338
dc.identifier.other10.1093/tropej/fmn114
dc.identifier.urihttp://hdl.handle.net/10019.1/12282
dc.subjectantiretrovirus agent
dc.subjectganciclovir
dc.subjectomeprazole
dc.subjectAfrica south of the Sahara
dc.subjectarticle
dc.subjectCD4 lymphocyte count
dc.subjectchild
dc.subjectclinical article
dc.subjectclinical feature
dc.subjectcontrolled study
dc.subjectCryptosporidium
dc.subjectcytomegalovirus infection
dc.subjectdysphagia
dc.subjectesophagitis
dc.subjectfemale
dc.subjectgastritis
dc.subjectgastrointestinal endoscopy
dc.subjectgastrointestinal hemorrhage
dc.subjectHelicobacter pylori
dc.subjecthighly active antiretroviral therapy
dc.subjecthistopathology
dc.subjecthuman
dc.subjectHuman immunodeficiency virus infection
dc.subjectinfant
dc.subjectmale
dc.subjectvomiting
dc.titleEndoscopy findings in HIV-infected children from sub-Saharan Africa
dc.typeArticle
Files
Collections
Stellenbosch University - Scopus Publications