Assessment of the α/ß ratios for arteriovenous malformations, meningiomas, acoustic neuromas, and the optic chiasma
dc.contributor.author | Vernimmen F.J.A.I. | |
dc.contributor.author | Slabbert J.P. | |
dc.date.accessioned | 2011-05-15T16:16:44Z | |
dc.date.available | 2011-05-15T16:16:44Z | |
dc.date.issued | 2010 | |
dc.description.abstract | Purpose: To determine alpha/beta (α/ß) values of arteriovenous malformations (AVM), meningiomas, acoustic neuromas (AN), and the optic chiasma using clinical data. Methods and materials:Data of dose/fractionation schedules form the literature, iso-effective for a specific clinical outcome, were analysed using the Fraction Equivalent plot (FE) method and the Tucker method. Established safe dose/fractionation schedules for the optic chiasma were used to determine its α/ß value. Results:With the FE plot method, an alpha/beta value of 3.76 Gray (Gy) (95 confidence level [CL]: 2.84.6 Gy) for meningiomas, 2.4 Gy (95 CL: 0.83.9 Gy) for acoustic neuroma, and 14.7 Gy (95 CL: 3.825.7 Gy) for arteriovenous malformations were determined. The respective alpha/beta values using the Tucker method were 3.3 Gy (95CL: 2.26.8 Gy), 1.77 Gy (95CL: 1.33.0 Gy) and-57 Gy (95CL:-79.6 to 35.2 Gy). No meaningful α/ß values could be determined for the optic chiasma. Conclusion:Acoustic neuromas with a low α/ß value would show no lesion intrinsic benefit from fractionation. Meningiomas probably benefit from a hypofractionated schedule. The high α/ß value for AVM can be explained but needs further research. Fractionation versus radiosurgery can be considered when the primary objective is to avoid normal tissue damage. © 2010 Informa UK Ltd. | |
dc.description.version | Article | |
dc.identifier.citation | International Journal of Radiation Biology | |
dc.identifier.citation | 86 | |
dc.identifier.citation | 6 | |
dc.identifier.issn | 09553002 | |
dc.identifier.other | 10.3109/09553001003667982 | |
dc.identifier.uri | http://hdl.handle.net/10019.1/13912 | |
dc.subject | acoustic neurinoma | |
dc.subject | arteriovenous malformation | |
dc.subject | article | |
dc.subject | controlled study | |
dc.subject | human | |
dc.subject | meningioma | |
dc.subject | optic chiasm | |
dc.subject | outcome assessment | |
dc.subject | priority journal | |
dc.subject | radiation dose fractionation | |
dc.subject | radiation response | |
dc.subject | radiation safety | |
dc.subject | radiosurgery | |
dc.subject | treatment response | |
dc.subject | meta analysis | |
dc.subject | neuroma | |
dc.subject | radiation exposure | |
dc.subject | Arteriovenous Malformations | |
dc.subject | Dose Fractionation | |
dc.subject | Humans | |
dc.subject | Meningeal Neoplasms | |
dc.subject | Meningioma | |
dc.subject | Neuroma, Acoustic | |
dc.subject | Optic Chiasm | |
dc.title | Assessment of the α/ß ratios for arteriovenous malformations, meningiomas, acoustic neuromas, and the optic chiasma | |
dc.type | Article |