The effect of baked areca nut extract on the growth of buccal mucosa fibroblasts from healthy non-areca nut chewers.

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dc.contributor.authorvan Wyk C.W.
dc.contributor.authorde Miranda C.M.
dc.contributor.authorOlivier A.
dc.contributor.authorvan der Bijl P.
dc.date.accessioned2011-05-15T15:58:02Z
dc.date.available2011-05-15T15:58:02Z
dc.date.issued1996
dc.description.abstractOral submucous fibrosis is a serious oral disease associated with the habit of chewing areca nut. The habit is relatively common among South Africans of Indian descent. The aim of this study was to observe the effect on growth of buccal mucosa fibroblasts derived from healthy individuals not practising the areca nut habit when the cells are exposed to nut extract. Fibroblast cell-lines from 6 individuals were grown in medium without extract and medium containing 50 and 100 [symbol: see text] g/ml extract of baked nut for 8 days. Cells not exposed to the nut extract behaved homogeneously. Reaction to the nut extracts, however, was dissimilar. The cells of 5 individuals showed no discernable reaction to the extracts while in one instance, the cells of a healthy adult male with no physical disabilities, showed marked growth inhibition. Thus, the finding indicates that when the effect of the nut or its constituents are tested on cells, it is necessary to use several cell-lines of the same cell type or a cell-line of which the growth parameters are standardized.
dc.description.versionArticle
dc.identifier.citationThe Journal of the Dental Association of South Africa = Die Tydskrif van die Tandheelkundige Vereniging van Suid-Afrika
dc.identifier.citation51
dc.identifier.citation1
dc.identifier.issn118516
dc.identifier.urihttp://hdl.handle.net/10019.1/10738
dc.subjectplant extract
dc.subjectadult
dc.subjectarticle
dc.subjectbetel nut
dc.subjectcell culture
dc.subjectchemistry
dc.subjectcooking
dc.subjectcytology
dc.subjectdose response
dc.subjectdrug effect
dc.subjectfemale
dc.subjectfibroblast
dc.subjecthuman
dc.subjectmale
dc.subjectmedicinal plant
dc.subjectmouth mucosa
dc.subjectreference value
dc.subjecttime
dc.subjectAdult
dc.subjectAreca
dc.subjectCells, Cultured
dc.subjectCookery
dc.subjectDose-Response Relationship, Drug
dc.subjectFemale
dc.subjectFibroblasts
dc.subjectHumans
dc.subjectMale
dc.subjectMouth Mucosa
dc.subjectPlant Extracts
dc.subjectPlants, Medicinal
dc.subjectReference Values
dc.subjectTime Factors
dc.titleThe effect of baked areca nut extract on the growth of buccal mucosa fibroblasts from healthy non-areca nut chewers.
dc.typeArticle
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