Oestrogen supplementation in gamete intrafallopian transfer (GIFT) - A prospective randomised study

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dc.contributor.authorde Decker A.P.H.
dc.contributor.authorKruger T.F.
dc.contributor.authorSiebert T.I.
dc.contributor.authorvan der Merwe J.P.
dc.contributor.authorLombard C.J.
dc.date.accessioned2011-05-15T16:18:05Z
dc.date.available2011-05-15T16:18:05Z
dc.date.issued2005
dc.description.abstractObjective. To investigate the impact of oestrogen supplementation from the early luteal to the late proliferative phase on biochemical and ongoing pregnancy rates in gamete intrallopian transfer [GIFT]. Methods. Ninety-five patients were assigned to clomiphene citrate-human menopausal gonadotrophin (hMG)-induced GIFT cycles, with or without the use of oestrogen support (oral administration of estradiol valerate). The main outcome measure were biochemical pregnancy rate and clinical pregnancy rate. Results. The biochemical pregnancy rate was 38.09% in the oestrogen group v. 22.9% in the control group (p = 0.096, 96% CI: 5.7 - 37.3%). The clinical pregnancy rate in the oestrogen supplementation group was 23.8% v. 14.58% in the control group (p = 0.1988, 95% CI: 10.3 - 31.7%. Conclusion. Although the results of this study shows no significant difference, there is a clinical trend in favour of giving oestrogen support.
dc.description.versionArticle
dc.identifier.citationSouth African Journal of Obstetrics and Gynaecology
dc.identifier.citation11
dc.identifier.citation1
dc.identifier.issn00382329
dc.identifier.urihttp://hdl.handle.net/10019.1/14501
dc.subjectchorionic gonadotropin
dc.subjectclomifene citrate
dc.subjectestradiol valerate
dc.subjectfollitropin
dc.subjecthuman menopausal gonadotropin
dc.subjectluteinizing hormone
dc.subjectperganol
dc.subjectprogesterone
dc.subjectadult
dc.subjectarticle
dc.subjectbiochemistry
dc.subjectclinical trial
dc.subjectconfidence interval
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdrug response
dc.subjectfemale
dc.subjectfemale infertility
dc.subjectgamete intrafallopian transfer
dc.subjecthuman
dc.subjectluteal phase
dc.subjectmajor clinical study
dc.subjectoocyte maturation
dc.subjectpregnancy rate
dc.subjectprospective study
dc.subjectrandomized controlled trial
dc.subjectstatistical analysis
dc.subjectstatistical significance
dc.subjecttreatment indication
dc.titleOestrogen supplementation in gamete intrafallopian transfer (GIFT) - A prospective randomised study
dc.typeArticle
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