Cerebrospinal fluid pyrazinamide concentrations in children with tuberculous meningitis

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dc.contributor.authorDonald P.R.
dc.contributor.authorSeifart H.
dc.date.accessioned2011-05-15T16:17:39Z
dc.date.available2011-05-15T16:17:39Z
dc.date.issued1988
dc.description.abstractCerebrospinal fluid pyrazinamide concentrations were determined by high pressure liquid chromatography in 53 samples from 13 children who had tuberculous meningitis complicated by increased intracranial pressure. Peak concentrations of up to 50 μg/ml were achieved between 1 1/2 and 2 1/2 hours after pyrazinamide administration and in most cases a concentration of 20 μg/ml or more was achieved. We conclude that pyrazinamide easily gains entry into the cerebrospinal fluid of children with tuberculous meningitis and should be included in treatment regimens for that disease.
dc.description.versionArticle
dc.identifier.citationPediatric Infectious Disease Journal
dc.identifier.citation7
dc.identifier.citation7
dc.identifier.issn08913668
dc.identifier.urihttp://hdl.handle.net/10019.1/14311
dc.subjectpyrazinamide
dc.subjectage
dc.subjectcerebrospinal fluid
dc.subjectchild
dc.subjectclinical article
dc.subjectdrug determination
dc.subjecthuman
dc.subjectinfant
dc.subjectintravenous drug administration
dc.subjectmeningitis
dc.subjectnonhuman
dc.subjectpediatrics
dc.subjectpriority journal
dc.subjecttuberculosis
dc.subjectChild, Preschool
dc.subjectChromatography, High Pressure Liquid
dc.subjectHuman
dc.subjectInfant
dc.subjectIntracranial Pressure
dc.subjectPyrazinamide
dc.subjectSupport, Non-U.S. Gov't
dc.subjectTime Factors
dc.subjectTuberculosis, Meningeal
dc.titleCerebrospinal fluid pyrazinamide concentrations in children with tuberculous meningitis
dc.typeArticle
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