Selectivity in overlapping MAP kinase cascades

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dc.contributor.authorSomsen, O. J. G.en_ZA
dc.contributor.authorSiderius, M.en_ZA
dc.contributor.authorBauer, Florianen_ZA
dc.contributor.authorSnoep, J. L.en_ZA
dc.contributor.authorWesterhoff, H. V.en_ZA
dc.date.accessioned2011-05-15T15:59:50Z
dc.date.available2011-05-15T15:59:50Z
dc.date.issued2002
dc.description.abstractSome protein kinases operate in more than one mitogen-activated protein-kinase (MAPK) cascade. We here address the question whether specificity of the cascades necessitates physical sequestration of these "promiscuous" kinases (e.g. by binding to scaffolds). A model is constructed, in which two MAPK cascades depend on a single MAP-kinase kinase that is not sequestered in two subpopulations. We show that in this model selective signal transduction is possible provided that there is an additional interaction at the MAP-kinase level, there is no simultaneous activation of more than one response by either signal. We discuss a number of additional interactions that can generate the selectivity, as well as some kinetic features by which this mechanism may be recognized experimentally. © 2002 Elsevier Science Ltd. All rights reserved.
dc.description.versionArticle
dc.identifier.citationJournal of Theoretical Biology
dc.identifier.citation218
dc.identifier.citation3
dc.identifier.issn225193
dc.identifier.other10.1006/jtbi.2002.3082
dc.identifier.urihttp://hdl.handle.net/10019.1/11391
dc.subjectmitogen activated protein kinase
dc.subjectmitogen activated protein kinase kinase
dc.subjectmitogen activated protein kinase kinase kinase
dc.subjectenzyme
dc.subjectarticle
dc.subjectenzyme activation
dc.subjectenzyme activity
dc.subjectenzyme mechanism
dc.subjectenzyme phosphorylation
dc.subjectenzyme specificity
dc.subjectMichaelis constant
dc.subjectmodel
dc.subjectpriority journal
dc.subjectsignal transduction
dc.subjectAdaptation, Physiological
dc.subjectAnimals
dc.subjectEnzyme Activation
dc.subjectMAP Kinase Signaling System
dc.subjectMitogen-Activated Protein Kinase Kinases
dc.subjectMitogen-Activated Protein Kinases
dc.subjectModels, Chemical
dc.titleSelectivity in overlapping MAP kinase cascades
dc.typeArticle
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