Lipid peroxidation and platelet membrane fluidity-implications for Alzheimer's disease?

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dc.contributor.authorVan Rensburg S.
dc.contributor.authorDaniels W.M.U.
dc.contributor.authorVan Zyl J.
dc.contributor.authorPotocnik F.C.V.
dc.contributor.authorVan Der Walt B.J.
dc.contributor.authorTaljaard J.J.F.
dc.date.accessioned2011-05-15T16:17:30Z
dc.date.available2011-05-15T16:17:30Z
dc.date.issued1994
dc.description.abstractIn humans, the fluidity of cell membranes generally decreases with age. Unexpectedly, several laboratories have found increased fluidity of platelet membranes (mainly endoplasmic reticulum) in patients with Alzheimer's disease (AD) compared with controls. In the present study, free radical induced lipid peroxidation was found to increase the fluidity of platelet membranes. Hydroxyl radicals were generated in the presence of Fe2+ and EDTA at low concentrations of ascorbate. It is hypothesised that platelet membranes are unable to restore their microviscosity by incorporating cholesterol. There may be a link between the result obtained in this study, the recently discovered decreased cholesterol content of affected AD neuronal membranes, and the increased frequency of ε4 apolipoprotein E (a cholesterol carrier) found in AD patients.
dc.description.versionArticle
dc.identifier.citationNeuroReport
dc.identifier.citation5
dc.identifier.citation17
dc.identifier.issn09594965
dc.identifier.urihttp://hdl.handle.net/10019.1/14243
dc.subjectapolipoprotein e
dc.subjectascorbic acid
dc.subjectcholesterol
dc.subjectfree radical
dc.subjectalzheimer disease
dc.subjectarticle
dc.subjecthuman
dc.subjecthuman cell
dc.subjectlipid peroxidation
dc.subjectmembrane fluidity
dc.subjectpriority journal
dc.subjectthrombocyte
dc.subjectAlzheimer Disease
dc.subjectAscorbic Acid
dc.subjectBlood Platelets
dc.subjectFluorescence Polarization
dc.subjectHuman
dc.subjectLipid Peroxides
dc.subjectMembrane Fluidity
dc.subjectReference Values
dc.subjectSupport, Non-U.S. Gov't
dc.subjectThiobarbituric Acid Reactive Substances
dc.subjectViscosity
dc.titleLipid peroxidation and platelet membrane fluidity-implications for Alzheimer's disease?
dc.typeArticle
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