Low rate of genomic repatterning in Xenarthra inferred from chromosome painting data

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dc.contributor.authorDobigny G.
dc.contributor.authorYang F.
dc.contributor.authorO'Brien P.C.M.
dc.contributor.authorVolobouev V.
dc.contributor.authorKovacs A.
dc.contributor.authorPieczarka J.C.
dc.contributor.authorFerguson-Smith M.A.
dc.contributor.authorRobinson T.J.
dc.date.accessioned2011-05-15T15:59:04Z
dc.date.available2011-05-15T15:59:04Z
dc.date.issued2005
dc.description.abstractComparative cytogenetic studies on Xenarthra, one of the most basal mammalian clades in the Placentalia, are virtually absent, being restricted largely to descriptions of conventional karyotypes and diploid numbers. We present a molecular cytogenetic comparison of chromosomes from the two-toed (Choloepus didactylus, 2n = 65) and three-toed sloth species (Bradypus tridactylus, 2n = 52), an anteater (Tamandua tetradactyla, 2n = 54) which, together with some data on the six-banded armadillo (Euphractus sexcinctus, 2n = 58), collectively represent all the major xenarthran lineages. Our results, based on interspecific chromosome painting using flow-sorted two-toed sloth chromosomes as painting probes, show the sloth species to be karyotypically closely related but markedly different from the anteater. We also test the synteny disruptions and segmental associations identified within Pilosa (anteaters and sloths) against the chromosomes of the six-banded armadillo as outgroup taxon. We could thus polarize the 35 non-ambiguously identified chromosomal changes characterizing the evolution of the anteater and sloth genomes and map these to a published sequence-based phylogeny for the group. These data suggest a low rate of genomic repatterning when placed in the context of divergence estimates based on molecular and fossil data. Finally, our results provide a glimpse of a likely ancestral karyotype for the extant Xenarthra, a pivotal group for understanding eutherian genome evolution. © Springer 2005.
dc.description.versionArticle
dc.identifier.citationChromosome Research
dc.identifier.citation13
dc.identifier.citation7
dc.identifier.issn9673849
dc.identifier.other10.1007/s10577-005-1002-9
dc.identifier.urihttp://hdl.handle.net/10019.1/10987
dc.subjectanimal cell
dc.subjectanteater
dc.subjectarmadillo
dc.subjectarticle
dc.subjectchromosome analysis
dc.subjectchromosome painting
dc.subjectcladistics
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectdiploidy
dc.subjectEdentata
dc.subjectgene disruption
dc.subjectgenetic association
dc.subjectgenetic variability
dc.subjectgenome analysis
dc.subjectgenome imprinting
dc.subjectinterspecific relationship
dc.subjectkaryotype
dc.subjectkaryotype evolution
dc.subjectmale
dc.subjectmolecular evolution
dc.subjectmolecular phylogeny
dc.subjectnonhuman
dc.subjectplesiomorphy
dc.subjectpriority journal
dc.subjectsequence analysis
dc.subjectsloth
dc.subjectsynteny
dc.subjecttaxonomy
dc.subjectAnimals
dc.subjectChromosome Banding
dc.subjectChromosome Painting
dc.subjectChromosomes, Mammalian
dc.subjectCytogenetics
dc.subjectEvolution, Molecular
dc.subjectGenome
dc.subjectIn Situ Hybridization, Fluorescence
dc.subjectKaryotyping
dc.subjectPhylogeny
dc.subjectSynteny
dc.subjectXenarthra
dc.subjectBradypus infuscatus
dc.subjectBradypus tridactylus
dc.subjectCholoepus didactylus
dc.subjectEdentata
dc.subjectEuphractus sexcinctus
dc.subjectEutheria
dc.subjectMammalia
dc.subjectMegalonychidae
dc.subjectMyrmecophagidae
dc.subjectTamandua tetradactyla
dc.titleLow rate of genomic repatterning in Xenarthra inferred from chromosome painting data
dc.typeArticle
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