Effects of adriamycin on heart and skeletal muscle chromatin

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dc.contributor.authorVan Helden P.D.
dc.contributor.authorWiid I.J.F.
dc.date.accessioned2011-05-15T16:01:18Z
dc.date.available2011-05-15T16:01:18Z
dc.date.issued1982
dc.description.abstractInteractions between adriamycin (ADM) and chromatin from heart and skeletal muscle from 15 day-old chicken emryos were investigated. Adriamycin interacts with the DNA of chromatin and this interaction is modified by the chromatin proteins. One of the effects of this interaction is an increase in the melting temperature (T(m)) of the DNA, where adriamycin is observed to increase the T(m) of heart chromatin to a greater extent than skeletal muscle chromatin. Adriamycin also inhibits in vitro DNA and RNA synthesis in isolated chromatin and nuclei. This inhibition is observed to be greater in heart muscle. Inhibition of transcription in the myocardium could be a major cause of adriamycin-induced cardiomyopathy.
dc.description.versionArticle
dc.identifier.citationBiochemical Pharmacology
dc.identifier.citation31
dc.identifier.citation6
dc.identifier.issn62952
dc.identifier.other10.1016/0006-2952(82)90330-6
dc.identifier.urihttp://hdl.handle.net/10019.1/11913
dc.subjectdoxorubicin
dc.subjectanimal experiment
dc.subjectcardiomyopathy
dc.subjectchicken
dc.subjectchromatin
dc.subjectdna drug complex
dc.subjectdna synthesis
dc.subjectembryo
dc.subjectheart
dc.subjectheart muscle
dc.subjectheredity
dc.subjectin vitro study
dc.subjectmuscle
dc.subjectrna synthesis
dc.subjectAnimal
dc.subjectChick Embryo
dc.subjectChromatin
dc.subjectDNA
dc.subjectDoxorubicin
dc.subjectHeart
dc.subjectMuscles
dc.subjectMyocardium
dc.subjectRNA
dc.titleEffects of adriamycin on heart and skeletal muscle chromatin
dc.typeArticle
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