Drug therapy in pregnancy: Carefully changing our approach

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dc.contributor.authorvan der Merwe H.
dc.contributor.authorHall D.
dc.date.accessioned2011-05-15T16:17:34Z
dc.date.available2011-05-15T16:17:34Z
dc.date.issued2008
dc.description.abstractMedical therapy in pregnancy is an inescapable scenario faced by all doctors. The fact that a vulnerable fetus is involved makes the situation all the more challenging. Almost all drugs on the market were not designed with pregnancy in mind and because of the fear of costly litigation, pharmaceutical companies are extremely reluctant to test and later endorse their products for use during pregnancy. Instead disclaimers are the norm. Nonetheless medical conditions in pregnant women do need to be treated. This demands that physicians understand the pregnancy physiology and fetal development, stay abreast of new information and maintain a flexible approach in order to best manage the mother and her unborn child. This article covers basic principles and then illustrates this flexible approach using three diagnostic areas where new information has recently become available.
dc.description.versionReview
dc.identifier.citationObstetrics and Gynaecology Forum
dc.identifier.citation18
dc.identifier.citation1
dc.identifier.issn10291962
dc.identifier.urihttp://hdl.handle.net/10019.1/14275
dc.subjectamitriptyline
dc.subjectanticonvulsive agent
dc.subjectantidepressant agent
dc.subjectbiguanide derivative
dc.subjectcarbamazepine
dc.subjectcitalopram
dc.subjectfluoxetine
dc.subjectfolic acid
dc.subjectglibenclamide
dc.subjectimipramine
dc.subjectinsulin
dc.subjectlamotrigine
dc.subjectmetformin
dc.subjectnortriptyline
dc.subjectoral antidiabetic agent
dc.subjectparoxetine
dc.subjectphenytoin
dc.subjectserotonin uptake inhibitor
dc.subjectsertraline
dc.subjectsulfonylurea derivative
dc.subjecttopiramate
dc.subjecttricyclic antidepressant agent
dc.subjectvalproic acid
dc.subjectvitamin K group
dc.subjectclinical trial
dc.subjectcongenital malformation
dc.subjectdepression
dc.subjectdiabetic diet
dc.subjectdrug absorption
dc.subjectdrug blood level
dc.subjectdrug choice
dc.subjectdrug contraindication
dc.subjectdrug efficacy
dc.subjectdrug indication
dc.subjectdrug metabolism
dc.subjectdrug penetration
dc.subjectdrug safety
dc.subjectdrug tolerability
dc.subjectdrug withdrawal
dc.subjectepilepsy
dc.subjectevidence based medicine
dc.subjectfetoplacental unit
dc.subjectfetus development
dc.subjectglycemic control
dc.subjecthuman
dc.subjecthypoglycemia
dc.subjectkinesiotherapy
dc.subjectmaternal mortality
dc.subjectmaternal treatment
dc.subjectpatient counseling
dc.subjectpregnancy
dc.subjectpregnancy diabetes mellitus
dc.subjectpregnant woman
dc.subjectprescription
dc.subjectreview
dc.subjectrisk benefit analysis
dc.titleDrug therapy in pregnancy: Carefully changing our approach
dc.typeReview
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