Risperidone augmentation of serotonin reuptake inhibitors in obsessive- compulsive and related disorders

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dc.contributor.authorStein D.J.
dc.contributor.authorBouwer C.
dc.contributor.authorHawkridge S.
dc.contributor.authorEmsley R.A.
dc.date.accessioned2011-05-15T16:01:58Z
dc.date.available2011-05-15T16:01:58Z
dc.date.issued1997
dc.description.abstractBackground: While serotonin is the neurotransmitter most commonly implicated in obsessive-compulsive and related disorders, there is also evidence for dopaminergic mediation of these conditions. Indeed, augmentation of serotonin reuptake inhibitors with the atypical neuroleptic risperidone has been suggested to he useful in obsessive-compulsive disorder (OCD). Method: Charts of all patients treated in our OCD clinic with the combination of a serotonin reuptake inhibitor and risperidone were reviewed. Demographic details of patients and clinical response to this pharmacotherapeutic strategy were tabulated. Results: A series of patients with OCD (N = 8), trichotillomania (N = 5), and Tourette's syndrome (N = 3) who were refractory to treatment with serotonin reuptake inhibitors had received risperidone augmentation. In a number of cases, this strategy proved clinically effective. However, a minority of patients experienced significant adverse effects. Conclusion: Patients with OCD and related disorders are not infrequently refractory to treatment with serotonin reuptake inhibitors. Controlled trials of risperidone augmentation in such patients seem warranted. In particular, it is necessary to determine an appropriate dose range to minimize adverse effects.
dc.description.versionArticle
dc.identifier.citationJournal of Clinical Psychiatry
dc.identifier.citation58
dc.identifier.citation3
dc.identifier.issn1606689
dc.identifier.urihttp://hdl.handle.net/10019.1/12239
dc.subjectcitalopram
dc.subjectclomipramine
dc.subjectclozapine
dc.subjectfluoxetine
dc.subjecthaloperidol
dc.subjectneuroleptic agent
dc.subjectparoxetine
dc.subjectpimozide
dc.subjectrisperidone
dc.subjectritanserin
dc.subjectserotonin uptake inhibitor
dc.subjectadolescent
dc.subjectadult
dc.subjectarticle
dc.subjectclinical article
dc.subjectdrug potentiation
dc.subjectgilles de la tourette syndrome
dc.subjecthuman
dc.subjectobsession
dc.subjectpriority journal
dc.subjecttrichotillomania
dc.subjectAdult
dc.subjectDrug Therapy, Combination
dc.subjectFemale
dc.subjectHospital Records
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectObsessive-Compulsive Disorder
dc.subjectPsychiatric Status Rating Scales
dc.subjectRisperidone
dc.subjectSerotonin Uptake Inhibitors
dc.subjectTourette Syndrome
dc.subjectTrichotillomania
dc.titleRisperidone augmentation of serotonin reuptake inhibitors in obsessive- compulsive and related disorders
dc.typeArticle
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