Defining the ancestral eutherian karyotype: A cladistic interpretation of chromosome painting and genome sequence assembly data

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dc.contributor.authorRobinson T.J.
dc.contributor.authorRuiz-Herrera A.
dc.date.accessioned2011-05-15T15:59:03Z
dc.date.available2011-05-15T15:59:03Z
dc.date.issued2008
dc.description.abstractA cladistic analysis of genome assemblies (syntenic associations) for eutherian mammals against two distant outgroup species-opossum and chicken-permitted a refinement of the 46-chromosome karyotype formerly inferred in the ancestral eutherian. We show that two intact chromosome pairs (corresponding to human chromosomes 13 and 18) and three conserved chromosome segments (10q, 19p and 8q in the human karyotype) are probably symplesiomorphic for Eutheria because they are also present as unaltered orthologues in one or both outgroups. Seven additional syntenies (4q/8p/4pq, 3p/21, 14/15, 10p/12pq/22qt, 19q/16q, 16p/7a and 12qt/22q), each involving human chromosomal segments that in various combinations correspond to complete chromosomes in the ancestral eutherian karyotype, are also present in one or both outgroup taxa and thus are probable symplesiomorphies for Eutheria. Interestingly, several of the symplesiomorphic characters identified in chicken and/or opossum are present in more distant outgroups such as pufferfish and zebrafish (for example 3p/21, 14/15, 19q/16q and 16p/7a), suggesting their retention since vertebrate common ancestry ∼450 million years ago. However, eight intact pairs (corresponding to human chromosomes 1, 5, 6, 9, 11, 17, 20 and the X) and three chromosome segments (7b, 2p-q13 and 2q13-qter) are derived characters potentially consistent with eutherian monophyly. Our analyses clarify the distinction between shared-ancestral and shared-derived homology in the eutherian ancestral karyotype. © 2008 Springer Science+Business Media B.V.
dc.description.versionArticle
dc.identifier.citationChromosome Research
dc.identifier.citation16
dc.identifier.citation8
dc.identifier.issn9673849
dc.identifier.other10.1007/s10577-008-1264-0
dc.identifier.urihttp://hdl.handle.net/10019.1/10978
dc.subjectarticle
dc.subjectchicken
dc.subjectchromosome
dc.subjectchromosome 1
dc.subjectchromosome 10p
dc.subjectchromosome 10q
dc.subjectchromosome 11
dc.subjectchromosome 13
dc.subjectchromosome 14
dc.subjectchromosome 15
dc.subjectchromosome 16p
dc.subjectchromosome 16q
dc.subjectchromosome 17
dc.subjectchromosome 18
dc.subjectchromosome 19p
dc.subjectchromosome 19q
dc.subjectchromosome 20
dc.subjectchromosome 21
dc.subjectchromosome 22q
dc.subjectchromosome 2p
dc.subjectchromosome 3p
dc.subjectchromosome 4q
dc.subjectchromosome 5
dc.subjectchromosome 6
dc.subjectchromosome 8p
dc.subjectchromosome 8q
dc.subjectchromosome 9
dc.subjectchromosome painting
dc.subjectchromosome pairing
dc.subjectcladistics
dc.subjectgene sequence
dc.subjecthuman
dc.subjectkaryotype
dc.subjectmonophyly
dc.subjectnonhuman
dc.subjectopossum
dc.subjectpriority journal
dc.subjectpuffer fish
dc.subjectX chromosome
dc.subjectzebra fish
dc.subjectAnimals
dc.subjectChromosome Painting
dc.subjectChromosomes, Mammalian
dc.subjectEvolution, Molecular
dc.subjectKaryotyping
dc.subjectMammals
dc.subjectPhylogeny
dc.subjectSpecies Specificity
dc.subjectSynteny
dc.subjectDanio rerio
dc.subjectDidelphidae
dc.subjectEutheria
dc.subjectTetraodontidae
dc.subjectVertebrata
dc.titleDefining the ancestral eutherian karyotype: A cladistic interpretation of chromosome painting and genome sequence assembly data
dc.typeArticle
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