Subtypes of acute postinfectious glomerulonephritis: A clinico-pathological correlation

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dc.contributor.authorEdelstein C.L.
dc.contributor.authorBates W.D.
dc.date.accessioned2011-05-15T16:16:06Z
dc.date.available2011-05-15T16:16:06Z
dc.date.issued1992
dc.description.abstractThe case records and histopathology of 42 adults with the characteristic light and electron microscopic features of Acute Postinfectious Glomerulonephritis (APGN) were studied. The biopsies were divided into three subtypes depending on the form and distribution of subepithelial 'humps' and other immune-complex deposits on electron microscopy (EM): the 'starry sky', 'garland' and 'mesangial' patterns. There was no significant difference between the three subtypes with regard to age, hypertension, creatinine, anti-streptolysin 0 titer and low serum complement levels on presentation. The 'garland' subtype had significantly more proteinuria than both the 'starry sky' (p = 0.04) and 'mesangial' (p = 0.003) subtypes. The 'mesangial' pattern had a lesser degree of cellular proliferation and leukocytosis in the glomeruli than the other subtypes. The 'starry sky' subtype was present in 4 of the 5 cases of crescentic nephritis and in 6 of the 7 patients with a chronic course. Our study suggests that the higher degree of proteinuria in the 'garland' subtype and the chronic course of the 'starry sky' subtype are the main clinical features that distinguish the three histological subtypes. Our patients, from a developing community with poor socio-economic conditions, had a poor prognosis.
dc.description.versionArticle
dc.identifier.citationClinical Nephrology
dc.identifier.citation38
dc.identifier.citation6
dc.identifier.issn03010430
dc.identifier.urihttp://hdl.handle.net/10019.1/13631
dc.subjectcomplement
dc.subjectcreatinine
dc.subjectacute glomerulonephritis
dc.subjectadult
dc.subjectarticle
dc.subjectcell proliferation
dc.subjectclinical article
dc.subjectclinical feature
dc.subjectcreatinine blood level
dc.subjectdisease classification
dc.subjectelectron microscopy
dc.subjectfollow up
dc.subjectglomerulus
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman tissue
dc.subjecthypertension
dc.subjectimmune complex deposition
dc.subjectkidney biopsy
dc.subjectleukocytosis
dc.subjectmorphology
dc.subjectpriority journal
dc.subjectprognosis
dc.subjectproteinuria
dc.subjectsocial status
dc.subjectstreptolysin titer
dc.subjectAcute Disease
dc.subjectAdult
dc.subjectAntigen-Antibody Complex
dc.subjectFemale
dc.subjectFluorescent Antibody Technique
dc.subjectFollow-Up Studies
dc.subjectGlomerular Mesangium
dc.subjectGlomerulonephritis
dc.subjectHuman
dc.subjectKidney Failure, Chronic
dc.subjectKidney Glomerulus
dc.subjectMale
dc.subjectMicroscopy, Electron
dc.subjectPrognosis
dc.subjectSupport, Non-U.S. Gov't
dc.subjectTime Factors
dc.titleSubtypes of acute postinfectious glomerulonephritis: A clinico-pathological correlation
dc.typeArticle
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