Influence of halogen salts on the production of the ochratoxins by Aspergillus ochraceus Wilh.

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dc.contributor.authorStander M.A.
dc.contributor.authorSteyn P.S.
dc.contributor.authorLubben A.
dc.contributor.authorMiljkovic A.
dc.contributor.authorMantle P.G.
dc.contributor.authorMarais G.J.
dc.date.accessioned2011-05-15T15:56:53Z
dc.date.available2011-05-15T15:56:53Z
dc.date.issued2000
dc.description.abstractThe first report of the biological production of bromo ochratoxin B by Aspergillus ochraceus Wilh. is presented as well as a study of the influence of potassium bromide, potassium iodide, potassium fluoride, and potassium chloride on the production of ochratoxin A and ochratoxin B. Potassium fluoride and potassium iodide inhibited the growth of the fungus, whereas potassium chloride substantially stimulated the production of ochratoxin A in shaken solid substrate fermentation on whole wheat or shredded wheat, generally giving a high yield of ochratoxins. Increasing levels of potassium bromide led to a decline in ochratoxin A production and an increase in bromo- ochratoxin B, ochratoxin B, and 4-hydroxy ochratoxin B. Nevertheless, A. ochraceus was much less versatile in the bromo analogues than other fungi, which produce metabolites containing chlorine. Analysis included aminopropyl solid-phase extraction column cleanup followed by quantitative analysis on reversed-phase HPLC using fluorescence detection and employing N-(5-chloro-2- hydroxybenzoyl)-phenylalanine as an internal standard.
dc.description.versionArticle
dc.identifier.citationJournal of Agricultural and Food Chemistry
dc.identifier.citation48
dc.identifier.citation5
dc.identifier.issn218561
dc.identifier.other10.1021/jf9912708
dc.identifier.urihttp://hdl.handle.net/10019.1/10094
dc.subjecthalogen
dc.subjectinorganic salt
dc.subjectochratoxin
dc.subjectpotassium bromide
dc.subjectpotassium chloride
dc.subjectpotassium fluoride
dc.subjectpotassium iodide
dc.subjectarticle
dc.subjectAspergillus ochraceus
dc.subjectbiosynthesis
dc.subjectchemical structure
dc.subjectchemistry
dc.subjectdrug effect
dc.subjectfermentation
dc.subjectfungus growth
dc.subjectmetabolism
dc.subjectnonhuman
dc.subjectquantitative assay
dc.subjectreversed phase high performance liquid chromatography
dc.subjectsolid phase extraction
dc.subjectAspergillus ochraceus
dc.subjectHalogens
dc.subjectOchratoxins
dc.subjectSalts
dc.titleInfluence of halogen salts on the production of the ochratoxins by Aspergillus ochraceus Wilh.
dc.typeArticle
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