A model for epithelial growth and epithelium-connective tissue interaction studies.

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dc.contributor.authorvan Wyk C.W.
dc.contributor.authorThompson I.O.
dc.date.accessioned2011-05-15T15:58:05Z
dc.date.available2011-05-15T15:58:05Z
dc.date.issued1992
dc.description.abstractThe aim of this study was to evaluate implanted ectocervical biopsy material as a model for morphological studies of normal and abnormal epithelial growth and epithelial-connective tissue interactions. Forty-five specimens were implanted in the flanks of nude (immunodeficient) mice and harvested at 1, 2, 3 and 6 weeks. Superficial necrosis of the epithelial layer with retention of parts of the basal cell layer were evident at 1 and 2 weeks. At 2 weeks granulation tissue enclosed the bases of the implants. Regrowth of epithelium on the surfaces and from the edges of the specimens was seen at 3 weeks. At 6 weeks the specimens were revascularized and the majority coated with a well developed unkeratinized stratified squamous epithelial layer resembling the epithelium of the ectocervix. It is concluded that specimens of human ectocervix, implanted in nude mice, offer the possibility for morphological studies of normal and abnormal epithelial growth and, if experimental difficulties can be overcome, of the epithelial-connective tissue interactions.
dc.description.versionArticle
dc.identifier.citationThe Journal of the Dental Association of South Africa = Die Tydskrif van die Tandheelkundige Vereniging van Suid-Afrika
dc.identifier.citation47
dc.identifier.citation5
dc.identifier.issn118516
dc.identifier.urihttp://hdl.handle.net/10019.1/10765
dc.subjectanimal
dc.subjectarticle
dc.subjectbiological model
dc.subjectconnective tissue cell
dc.subjectcytology
dc.subjectepithelium
dc.subjectepithelium cell
dc.subjectfemale
dc.subjectgrowth, development and aging
dc.subjectmouse
dc.subjectmouth mucosa
dc.subjectnude mouse
dc.subjectuterine cervix
dc.subjectAnimal
dc.subjectCervix Uteri
dc.subjectConnective Tissue Cells
dc.subjectEpithelial Cells
dc.subjectEpithelium
dc.subjectFemale
dc.subjectMice
dc.subjectMice, Nude
dc.subjectModels, Biological
dc.subjectMouth Mucosa
dc.titleA model for epithelial growth and epithelium-connective tissue interaction studies.
dc.typeArticle
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