Membrane fluidity of platelets and erythrocytes in patients with Alzheimer's disease and the effect of small amounts of aluminium on platelet and erythrocyte membranes

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dc.contributor.authorVan Rensburg S.J.
dc.contributor.authorCarstens M.E.
dc.contributor.authorPotocnik F.C.V.
dc.contributor.authorAucamp A.K.
dc.contributor.authorTaljaard J.J.F.
dc.contributor.authorKoch K.R.
dc.date.accessioned2011-05-15T16:17:27Z
dc.date.available2011-05-15T16:17:27Z
dc.date.issued1992
dc.description.abstractThe membrane fluidity of platelet and erythrocyte membranes in 10 Alzheimer's disease patients and 9 age-matched controls was studied. The platelet membranes of patients with Alzheimer's disease were found to be significantly more fluid than those of controls (p <0.02). However, erythrocyte membranes of Alzheimer patients were less fluid (more viscous) than those of controls (p <0.05). On further investigation of platelet and erythrocyte membranes obtained from healthy volunteers, the fluidity was found to change with increasing aluminium concentrations. When aluminium ammonium sulphate (0.01 - 10 μM) was added to membrane suspensions, the fluidity of platelet membranes was increased, whereas the fluidity of erythrocyte membranes was decreased (i.e. the microviscosity was increased).
dc.description.versionArticle
dc.identifier.citationNeurochemical Research
dc.identifier.citation17
dc.identifier.citation8
dc.identifier.issn03643190
dc.identifier.other10.1007/BF00969020
dc.identifier.urihttp://hdl.handle.net/10019.1/14221
dc.subjectaluminum sulfate
dc.subjectammonium sulfate
dc.subjectaged
dc.subjectalzheimer disease
dc.subjectarticle
dc.subjectcell membrane fluidity
dc.subjectcell suspension
dc.subjectcontrolled study
dc.subjecterythrocyte membrane
dc.subjecthuman
dc.subjecthuman cell
dc.subjectpriority journal
dc.subjectthrombocyte membrane
dc.subjectviscosity
dc.subjectAluminum
dc.subjectAlzheimer Disease
dc.subjectBlood Platelets
dc.subjectCell Membrane
dc.subjectErythrocyte Membrane
dc.subjectHuman
dc.subjectMembrane Fluidity
dc.subjectSupport, Non-U.S. Gov't
dc.subjectViscosity
dc.titleMembrane fluidity of platelets and erythrocytes in patients with Alzheimer's disease and the effect of small amounts of aluminium on platelet and erythrocyte membranes
dc.typeArticle
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