Dihydropteroate synthase and novel dihydrofolate reductase gene mutations in strains of Pneumocystis jirovecii from South Africa

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dc.contributor.authorRobberts F.J.L.
dc.contributor.authorChalkley L.J.
dc.contributor.authorWeyer K.
dc.contributor.authorGoussard P.
dc.contributor.authorLiebowitz L.D.
dc.date.accessioned2011-05-15T15:56:56Z
dc.date.available2011-05-15T15:56:56Z
dc.date.issued2005
dc.description.abstractDihydropteroate synthase (DHPS) gene mutations have raised concerns about emerging sulfonamide resistance in Pneumocystis jirovecii. DHPS and dihydrofolate reductase (DHFR) gene products were amplified in clinical specimens from South African patients. One of 53 DHPS genes sequenced contained the double mutation Thr55Ala Pro57Ser. DHFR gene mutations detected were Ala67Val and the new mutations Arg59Gly and C278T. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
dc.description.versionArticle
dc.identifier.citationJournal of Clinical Microbiology
dc.identifier.citation43
dc.identifier.citation3
dc.identifier.issn951137
dc.identifier.other10.1128/JCM.43.3.1443-1444.2005
dc.identifier.urihttp://hdl.handle.net/10019.1/10121
dc.subjectalanine
dc.subjectarginine
dc.subjectcotrimoxazole
dc.subjectdihydrofolate reductase
dc.subjectdihydropteroate synthase
dc.subjectgene product
dc.subjectglycine
dc.subjectsulfonamide
dc.subjectantibiotic resistance
dc.subjectarticle
dc.subjectbacterium identification
dc.subjectfungal gene
dc.subjectfungal strain
dc.subjectfungus mutation
dc.subjectgene amplification
dc.subjectgene mutation
dc.subjectgene sequence
dc.subjecthuman
dc.subjectnonhuman
dc.subjectnucleotide sequence
dc.subjectPneumocystis jiroveci
dc.subjectPneumocystis pneumonia
dc.subjectprevalence
dc.subjectpriority journal
dc.subjectSouth Africa
dc.subjectDihydropteroate Synthase
dc.subjectHumans
dc.subjectMutation
dc.subjectPneumocystis
dc.subjectTetrahydrofolate Dehydrogenase
dc.subjectPneumocystis jirovecii
dc.titleDihydropteroate synthase and novel dihydrofolate reductase gene mutations in strains of Pneumocystis jirovecii from South Africa
dc.typeArticle
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