The diagnostic yield and safety of ultrasound-assisted transthoracic biopsy of mediastinal masses
dc.contributor.author | Koegelenberg C.F.N. | |
dc.contributor.author | Diacon A.H. | |
dc.contributor.author | Irusen E.M. | |
dc.contributor.author | Von Groote-Bidlingmaier F. | |
dc.contributor.author | Mowlana A. | |
dc.contributor.author | Wright C.A. | |
dc.contributor.author | Louw M. | |
dc.contributor.author | Schubert P.T. | |
dc.contributor.author | Bolliger C.T. | |
dc.date.accessioned | 2011-05-15T15:57:31Z | |
dc.date.available | 2011-05-15T15:57:31Z | |
dc.date.issued | 2011 | |
dc.description.abstract | Background: Ultrasound (US)-assisted transthoracic biopsy offers a less invasive alternative to surgical biopsy in the setting of mediastinal masses. Objectives: The aim of this 1-year prospective study was to assess the diagnostic yield and safety of a novel single-session sequential approach of US-assisted transthoracic fine-needle aspirations (TTFNA) with rapid on-site evaluation (ROSE) followed by cutting needle biopsies (CNB) performed by physicians on patients with anterosuperior mediastinal masses. Methods: US-assisted TTFNA with ROSE was performed on 45 consecutive patients (49.5 ± 27.7 years, 24 males), immediately followed by CNB where a provisional diagnosis of epithelial carcinoma or tuberculosis could not be established, provided a safety range could be assured. Results: TTFNA alone was deemed adequate by means of ROSE in 27 (60%) patients. CNB could be performed in 17 of the remaining 18. The on-site diagnosis corresponded to the final diagnosis in 26/45 (57.8%). An accurate cytological diagnosis was made in 33 (73.3%), and was more likely to be diagnostic in epithelial carcinoma and tuberculosis (28/30) than all other pathologies (5/15, p < 0.001). CNB yielded a diagnosis in 15/17 (88.2%). Overall, 42/45 patients were diagnosed by the single-session approach (93.3%). The final diagnoses included 41 neoplasms, with small cell lung cancer (n = 13) the commonest diagnosis. We observed no pneumothorax or major haemorrhage. Conclusions: A single-session sequential approach of US-assisted TTFNA with ROSE followed by CNB, where indicated, has a high diagnostic yield for anterosuperior mediastinal masses, is safe and offers an alternative to surgical biopsy. Copyright © 2010 S. Karger AG, Basel. | |
dc.description.version | Article | |
dc.identifier.citation | Respiration | |
dc.identifier.citation | 81 | |
dc.identifier.citation | 2 | |
dc.identifier.issn | 257931 | |
dc.identifier.other | 10.1159/000322005 | |
dc.identifier.uri | http://hdl.handle.net/10019.1/10446 | |
dc.subject | adult | |
dc.subject | article | |
dc.subject | biopsy technique | |
dc.subject | clinical article | |
dc.subject | clinical evaluation | |
dc.subject | clinical trial | |
dc.subject | cutting needle biopsy | |
dc.subject | cytodiagnosis | |
dc.subject | diagnostic test accuracy study | |
dc.subject | diagnostic value | |
dc.subject | female | |
dc.subject | human | |
dc.subject | human tissue | |
dc.subject | lung carcinoma | |
dc.subject | lung small cell cancer | |
dc.subject | male | |
dc.subject | mediastinum mass | |
dc.subject | patient safety | |
dc.subject | priority journal | |
dc.subject | rapid on site evaluation | |
dc.subject | transthoracic aspiration | |
dc.subject | tuberculosis | |
dc.subject | ultrasound | |
dc.title | The diagnostic yield and safety of ultrasound-assisted transthoracic biopsy of mediastinal masses | |
dc.type | Article |