The effect of medial forebrain bundle lesion on thyrotropin secretion in the rat

Simple item page
dc.contributor.authorJaffer A.
dc.contributor.authorDaniels W.M.U.
dc.contributor.authorRussell V.A.
dc.contributor.authorTaljaard J.J.F.
dc.date.accessioned2011-05-15T16:17:27Z
dc.date.available2011-05-15T16:17:27Z
dc.date.issued1991
dc.description.abstractThe medial forebrain bundle (MFB) was partially lesioned with 6-hydroxydopamine (6-OHDA) in order to investigate the effect of deficient central noradrenergic regulation on thyrotropin (TSH) secretion in the rat. 6-OHDA injection into the MFB significantly reduced the noradrenaline (NA), dopamine (DA) and serotonin (5-HT) content of the whole hypothalamus. NA and 5-HT concentrations were also significantly decreased in the paraventricular nucleus (PVN). The MFB lesion did not affect the clonidine (250 μg/kg, i.p.) induced stimulation of TSH release or the isoproterenol (1 mg/kg i.p.) induced decrease in TSH levels. Thyrotropin releasing hormone (TRH, 5 μg/kg i.v.) caused a similar significant stimulation of TSH secretion in lesioned and non-lesioned rats. The present results do not support the hypothesis that the blunted TSH response to TRH observed in depressed patients results from a deficiency in noradrenergic neurotransmission.
dc.description.versionArticle
dc.identifier.citationNeurochemical Research
dc.identifier.citation16
dc.identifier.citation5
dc.identifier.issn03643190
dc.identifier.urihttp://hdl.handle.net/10019.1/14224
dc.subjectclonidine
dc.subjectisoprenaline
dc.subjectprotirelin
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcatecholamine brain level
dc.subjectcontrolled study
dc.subjectdrug sensitivity
dc.subjectmale
dc.subjectmedial forebrain bundle
dc.subjectnonhuman
dc.subjectnoradrenergic system
dc.subjectpriority journal
dc.subjectrat
dc.subjectthyroid hormone blood level
dc.subjectAnimal
dc.subjectClonidine
dc.subjectDopamine
dc.subjectIsoproterenol
dc.subjectMale
dc.subjectNorepinephrine
dc.subjectOxidopamine
dc.subjectProsencephalon
dc.subjectProtirelin
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.subjectSerotonin
dc.subjectSupport, Non-U.S. Gov't
dc.subjectThyrotropin
dc.subjectAnimalia
dc.titleThe effect of medial forebrain bundle lesion on thyrotropin secretion in the rat
dc.typeArticle
Files
Collections
Stellenbosch University - Scopus Tygerberg Hospital Publications