Diffusion MRI findings in Wilson's disease

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dc.contributor.authorSener R.N.
dc.date.accessioned2011-05-15T16:16:10Z
dc.date.available2011-05-15T16:16:10Z
dc.date.issued2003
dc.description.abstractSix patients having Wilson's disease were studied with diffusion MRI in order to characterize cerebral lesions. Diffusion MRI was obtained using the spin-echo, echo-planar sequence with a gradient strength of 30mT/m. The trace protocol was used in the axial imaging plane. Heavily diffusion-weighted (b=1000s/mm2) images, and the ADC (apparent diffusion coefficient) values from automatically generated ADC maps were studied. The ADC values of the normal brain parenchyma were available in 17 age-matched cases for comparison (ADC values, 0.85±0.11×10-3mm2/s). In Wilson's disease two distinct diffusion MRI patterns were observed by quantitative evaluations of the ADC maps; cytotoxic edema-like (ADC values, 0.52±0.03×10-3mm2/s), and vasogenic edema-like (ADC values, 1.42±0.17×10-3mm2/s) patterns. Diffusion imaging appears to be a promising sequence to evaluate the changes in the brain tissue in Wilson's disease at least by revealing two different patterns. © 2002 Elsevier Science Ltd. All rights reserved.
dc.description.versionArticle
dc.identifier.citationComputerized Medical Imaging and Graphics
dc.identifier.citation27
dc.identifier.citation1
dc.identifier.issn08956111
dc.identifier.other10.1016/S0895-6111(02)00047-2
dc.identifier.urihttp://hdl.handle.net/10019.1/13659
dc.subjectBrain
dc.subjectDiffusion
dc.subjectMagnetic resonance imaging
dc.subjectTissue
dc.subjectCerebral lesions
dc.subjectMedical imaging
dc.subjectadolescent
dc.subjectarticle
dc.subjectbrain edema
dc.subjectbrain tissue
dc.subjectchild
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcytotoxicity
dc.subjectdiagnostic imaging
dc.subjectdiffusion
dc.subjectfemale
dc.subjecthuman
dc.subjectimage analysis
dc.subjectmale
dc.subjectnuclear magnetic resonance imaging
dc.subjectpriority journal
dc.subjectquantitative analysis
dc.subjectWilson disease
dc.subjectAdolescent
dc.subjectBrain
dc.subjectCase-Control Studies
dc.subjectChild
dc.subjectDiffusion Magnetic Resonance Imaging
dc.subjectFemale
dc.subjectHepatolenticular Degeneration
dc.subjectHumans
dc.subjectMale
dc.titleDiffusion MRI findings in Wilson's disease
dc.typeArticle
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