Depressive symptoms at baseline predict fewer negative symptoms at follow-up in patients with first-episode schizophrenia

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dc.contributor.authorOosthuizen P.
dc.contributor.authorEmsley R.A.
dc.contributor.authorRoberts M.C.
dc.contributor.authorTurner J.
dc.contributor.authorKeyter L.
dc.contributor.authorKeyter N.
dc.contributor.authorTorreman M.
dc.date.accessioned2011-05-15T16:02:23Z
dc.date.available2011-05-15T16:02:23Z
dc.date.issued2002
dc.description.abstractThere is uncertainty regarding the prognostic value of depressive symptoms in schizophrenia, having previously been associated with both favourable and poor outcome. This study investigated the relationship between baseline depressive symptoms and treatment outcome at 6, 12 and 24 weeks in 80 subjects with first-episode schizophrenia or schizophreniform disorder in terms of PANSS total and subscale score changes. No significant association was found between baseline PANSS depression factor scores and PANSS total and subscore changes. However, a significant inverse correlation between baseline depression scores and negative scores at 6, 12 and 24 weeks was found (p=0.044, 0.023 and 0.012, respectively). Multiple regression analysis indicated that this finding could not be explained on the basis of age, gender or duration of untreated psychosis. These findings support previous work suggesting that high baseline depressive scores predict favourable outcome. © 2002 Elsevier Science B.V. All rights reserved.
dc.description.versionArticle
dc.identifier.citationSchizophrenia Research
dc.identifier.citation58
dc.identifier.citation03-Feb
dc.identifier.issn9209964
dc.identifier.other10.1016/S0920-9964(01)00375-9
dc.identifier.urihttp://hdl.handle.net/10019.1/12444
dc.subjectantidepressant agent
dc.subjecthaloperidol
dc.subjectlorazepam
dc.subjectorphenadrine
dc.subjectrisperidone
dc.subjecttrihexyphenidyl
dc.subjectadult
dc.subjectage
dc.subjectaged
dc.subjectarticle
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectcorrelation analysis
dc.subjectdepression
dc.subjectdisease association
dc.subjectextrapyramidal symptom
dc.subjectfemale
dc.subjectfollow up
dc.subjectgender
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmultiple regression
dc.subjectnegative syndrome
dc.subjectpriority journal
dc.subjectprognosis
dc.subjectpsychosis
dc.subjectschizophrenia
dc.subjectschizophreniform disorder
dc.subjectside effect
dc.subjectsymptomatology
dc.subjecttreatment outcome
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAntidepressive Agents
dc.subjectAntipsychotic Agents
dc.subjectDepression
dc.subjectDouble-Blind Method
dc.subjectDrug Administration Schedule
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHaloperidol
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPredictive Value of Tests
dc.subjectRisperidone
dc.subjectSchizophrenia
dc.subjectSchizophrenic Psychology
dc.subjectSeverity of Illness Index
dc.titleDepressive symptoms at baseline predict fewer negative symptoms at follow-up in patients with first-episode schizophrenia
dc.typeArticle
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