Systematic genetic nomenclature for type VII secretion systems

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dc.contributor.authorBitter, Wilberten_ZA
dc.contributor.authorHouben, Edith N. G.en_ZA
dc.contributor.authorBottai, Darriaen_ZA
dc.contributor.authorBrodin, Priscilleen_ZA
dc.contributor.authorBrown, Eric J.en_ZA
dc.contributor.authorCox, Jeffery S.en_ZA
dc.contributor.authorDerbyshire, Keithen_ZA
dc.contributor.authorFortune, Sarah M.en_ZA
dc.contributor.authorGao, Lian-Yongen_ZA
dc.contributor.authorLiu, Junen_ZA
dc.contributor.authorVan Pittius, Nicolaas C. Geyen_ZA
dc.contributor.authorPym, Alexander S.en_ZA
dc.contributor.authorRubin, Eric J.en_ZA
dc.contributor.authorSherman, David R.en_ZA
dc.contributor.authorCole, Stewart T.en_ZA
dc.contributor.authorBrosch, Rolanden_ZA
dc.date.accessioned2013-02-28T12:16:08Z
dc.date.available2013-02-28T12:16:08Z
dc.date.issued2009
dc.descriptionCITATION: Bitter, W., et al. 2009. Systematic genetic nomenclature for type VII secretion systems. PLoS Pathogens, 5(10): 1-6, doi: 10.1371/journal.ppat.1000507.
dc.descriptionThe original publication is available at http://journals.plos.org/plospathogens
dc.description.abstractMycobacteria, such as the etiological agent of human tuberculosis, Mycobacterium tuberculosis, are protected by an impermeable cell envelope composed of an inner cytoplasmic membrane, a peptidoglycan layer, an arabinogalactan layer, and an outer membrane. This second membrane consists of covalently linked, tightly packed long-chain mycolic acids [1,2] and noncovalently bound shorter lipids involved in pathogenicity [3–5]. To ensure protein transport across this complex cell envelope, mycobacteria use various secretion pathways, such as the SecA1-mediated general secretory pathway [6,7], an alternative SecA2-operated pathway [8], a twin-arginine translocation system [9,10], and a specialized secretion pathway variously named ESAT-6-, SNM-, ESX-, or type VII secretion [11–16]. The latter pathway, hereafter referred to as type VII secretion (T7S), has recently become a large and competitive research topic that is closely linked to studies of host–pathogen interactions of M. tuberculosis [17] and other pathogenic mycobacteria [16]. Molecular details are just beginning to be revealed [18–22] showing that T7S systems are complex machineries with multiple components and multiple substrates. Despite their biological importance, there has been a lack of a clear naming policy for the components and substrates of these systems. As there are multiple paralogous T7S systems within the Mycobacteria and orthologous systems in related bacteria, we are concerned that, without a unified nomenclature system, a multitude of redundant and obscure gene names will be used that will inevitably lead to confusion and hinder future progress. In this opinion piece we will therefore propose and introduce a systematic nomenclature with guidelines for name selection of new components that will greatly facilitate communication and understanding in this rapidly developing field of research.en_ZA
dc.description.urihttp://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1000507
dc.description.versionPublisher's versionen_ZA
dc.format.extent6 pages
dc.identifier.citationBitter, W., et al. 2009. Systematic genetic nomenclature for type VII secretion systems. PLoS Pathogens, 5(10): 1-6, doi: 10.1371/journal.ppat.1000507
dc.identifier.issn1553-7374 (online)
dc.identifier.issn1553-7366 (print)
dc.identifier.otherdoi: 10.1371/journal.ppat.1000507
dc.identifier.urihttp://hdl.handle.net/10019.1/79621
dc.language.isoen_ZAen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectSystematic genetic nomenclatureen_ZA
dc.subjectMycobacteria -- Nomenclatureen_ZA
dc.subjectType VII secretion systemsen_ZA
dc.subjectProtein pathwaysen_ZA
dc.titleSystematic genetic nomenclature for type VII secretion systemsen_ZA
dc.typeArticleen_ZA
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