Increased frequency of the transferrin C2 subtype in Alzheimer's disease

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dc.contributor.authorVan Rensburg S.J.
dc.contributor.authorCarstens M.E.
dc.contributor.authorPotocnik F.C.V.
dc.contributor.authorAucamp A.K.
dc.contributor.authorTaljaard J.J.F.
dc.date.accessioned2011-05-15T16:17:30Z
dc.date.available2011-05-15T16:17:30Z
dc.date.issued1993
dc.description.abstractSeveral genetic variants of transferrin can be separated by polyacrylamide gel isoelectric focusing. Studies by other workers have revealed that the genetic type Tf C2 has an increased frequency in certain malfunctions which are associated with the formation of free radicals, suggesting that the iron binding of Tf C2 promotes the formation of hydroxyl radicals. In our study population of 20 patients with Alzheimer's disease, 13 had the C2 genetic subtype. Since the frequency of C2 in the South African population is 0.136 (14%), this represents a significant increase (P < 0.005) in the appearance of this genetic subtype.
dc.description.versionArticle
dc.identifier.citationNeuroReport
dc.identifier.citation4
dc.identifier.citation11
dc.identifier.issn09594965
dc.identifier.urihttp://hdl.handle.net/10019.1/14244
dc.subjectfree radical
dc.subjecttransferrin
dc.subjectadult
dc.subjectaged
dc.subjectalzheimer disease
dc.subjectarticle
dc.subjectblood analysis
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectelectrophoresis
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectmale
dc.subjectAluminum
dc.subjectAlzheimer Disease
dc.subjectElectrophoresis, Polyacrylamide Gel
dc.subjectFree Radicals
dc.subjectHeterozygote
dc.subjectHomozygote
dc.subjectHuman
dc.subjectIron
dc.subjectIsoelectric Focusing
dc.subjectSouth Africa
dc.subjectSupport, Non-U.S. Gov't
dc.subjectTransferrin
dc.titleIncreased frequency of the transferrin C2 subtype in Alzheimer's disease
dc.typeArticle
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