An update on bronchopulmonary dysplasia: Is there a relationship to the development of childhood asthma?

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dc.contributor.authorSmith J.
dc.date.accessioned2011-05-15T16:17:21Z
dc.date.available2011-05-15T16:17:21Z
dc.date.issued2003
dc.description.abstractThere appears to be some interesting commonalities between asthma and BPD. The prevalence of both conditions is on the rise, both conditions tend to cluster in families, and they share wheezing phenotypes, i.e., mild-moderate reversible airway obstruction and a similar degree of response to pharmacological provocation. Furthermore, significant overlap exists with regard to the presence of elevated concentrations of airway inflammatory mediators concurrent with reduced levels of anti-inflammatory activity, in serum and BAL fluid, as well as histological evidence for airway 'remodelling'. Both BPD and asthma are characterized by increased smooth muscle contraction, and in asthma, the smooth muscle may be involved in the primary development of the asthmatic phenotype. Since wheezing is a common finding among children with BPD, an interesting question is whether BPD is a phenotypic variant of asthma? © 2003 Elsevier Ltd. All rights reserved.
dc.description.versionReview
dc.identifier.citationMedical Hypotheses
dc.identifier.citation61
dc.identifier.citation4
dc.identifier.issn03069877
dc.identifier.other10.1016/S0306-9877(03)00204-4
dc.identifier.urihttp://hdl.handle.net/10019.1/14179
dc.subjectbeta 2 adrenergic receptor stimulating agent
dc.subjectbronchodilating agent
dc.subjectcorticosteroid
dc.subjectipratropium bromide
dc.subjectlung surfactant
dc.subjectmethacholine
dc.subjectairway obstruction
dc.subjectantiinflammatory activity
dc.subjectasthma
dc.subjectchild
dc.subjectchildhood disease
dc.subjectclinical feature
dc.subjectclinical trial
dc.subjectdisease association
dc.subjecthistopathology
dc.subjecthuman
dc.subjectlung dysplasia
dc.subjectlung lavage
dc.subjectnonhuman
dc.subjectpathogenesis
dc.subjectphenotype
dc.subjectprevalence
dc.subjectpriority journal
dc.subjectreview
dc.subjectsmooth muscle contraction
dc.subjectwheezing
dc.subjectAsthma
dc.subjectBronchopulmonary Dysplasia
dc.subjectHumans
dc.subjectInfant, Newborn
dc.subjectModels, Theoretical
dc.subjectMuscle Contraction
dc.subjectMuscle, Smooth
dc.subjectPhenotype
dc.titleAn update on bronchopulmonary dysplasia: Is there a relationship to the development of childhood asthma?
dc.typeReview
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