Iodine concentration in breastmilk and urine among lactating women of Bhaktapur, Nepal

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dc.contributor.authorHenjum, Sigrunen_ZA
dc.contributor.authorKjellevold, Marianen_ZA
dc.contributor.authorUlak, Manjesworien_ZA
dc.contributor.authorChandyo, Ram K.en_ZA
dc.contributor.authorShrestha, Prakash S.en_ZA
dc.contributor.authorFroyland, Livaren_ZA
dc.contributor.authorStrydom, Emmerentia E.en_ZA
dc.contributor.authorDhansay, Muhammad A.en_ZA
dc.contributor.authorStrand, Tor A.en_ZA
dc.date.accessioned2018-08-31T12:25:59Z
dc.date.available2018-08-31T12:25:59Z
dc.date.issued2016-04-28
dc.descriptionCITATION: Henjum, S. et al. 2016. Iodine concentration in breastmilk and urine among lactating women of Bhaktapur, Nepal. Nutrients, 8(5), 255, doi:10.3390/nu8050255.
dc.descriptionThe original publication is available at http://www.mdpi.com
dc.description.abstractAdequate iodine concentration in breastmilk (BMIC) is essential for optimal neonatal thyroid hormone synthesis and neurological development in breastfed infants. For many decades, iodine deficiency has been a public health problem in Nepal. However, recently, excessive iodine intakes among Nepali infants have been reported. This study aimed to measure BMIC and urinary iodine concentration (UIC) among lactating women in a peri-urban area of Nepal. Iodine concentration was measured in spot urine (n = 485) and breastmilk samples (n = 291) of 500 randomly selected lactating women. The median (p25, p75) BMIC and median UIC were 250 (130, 370) µg/L and 230 (135–377) µg/L, respectively. Around 82% had BMIC > 100 µg/L, 61% had BMIC > 200 µg/L and 81% had UIC > 100 µg/L, 37% had >300 µg/L and 20% had >500 µg/L. In multiple linear regression models, time since birth (β 3.0, 95% CI (0.2, 5.0)) and UIC (β 1.0, 95% CI (0.1, 2.0)) were associated with BMIC, explaining 26% of the variance. A large proportion of the women had adequate BMIC and UIC; however, a subset had high iodine concentrations. These findings emphasize the importance of carefully monitoring iodine intake to minimize the risk of iodine excess and subsequently preventing transient iodine-induced hypothyroidism in breastfed infants.en_ZA
dc.description.urihttp://www.mdpi.com/2072-6643/8/5/255
dc.description.versionPublisher's version
dc.format.extent11 pages
dc.identifier.citationHenjum, S. et al. 2016. Iodine concentration in breastmilk and urine among lactating women of Bhaktapur, Nepal. Nutrients, 8(5), 255, doi:10.3390/nu8050255.
dc.identifier.issn2072-6643 (online)
dc.identifier.otherdoi:10.3390/nu8050255
dc.identifier.urihttp://hdl.handle.net/10019.1/104372
dc.language.isoen_ZAen_ZA
dc.publisherMDPI
dc.rights.holderAuthors retain copyright
dc.subjectBreastfeeding -- Nepalen_ZA
dc.subjectBreast milken_ZA
dc.subjectIodineen_ZA
dc.subjectUrineen_ZA
dc.subjectLactationen_ZA
dc.titleIodine concentration in breastmilk and urine among lactating women of Bhaktapur, Nepalen_ZA
dc.typeArticleen_ZA
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