Molecular analysis of HIV type 1 vif sequences from Cape Town, South Africa

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dc.contributor.authorJacobs G.B.
dc.contributor.authorNistal M.
dc.contributor.authorLaten A.
dc.contributor.authorVan Rensburg E.J.
dc.contributor.authorRethwilm A.
dc.contributor.authorPreiser W.
dc.contributor.authorBodem J.
dc.contributor.authorEngelbrecht S.
dc.date.accessioned2011-05-15T16:03:21Z
dc.date.available2011-05-15T16:03:21Z
dc.date.issued2008
dc.description.abstractSouth Africa has the highest number of HIV-1-infected individuals in the world, with HIV-1 subtype C prevailing. However, HIV-1 subtype C accessory genes are rarely characterized in the country. These genes are important for establishing viral pathogenesis. The Vif protein has been shown to counteract the antiretroviral activity of APOBEC3G/F cytidine deaminases. In this study an additional 50 HIV-1 vif sequences are characterized. These include 48 HIV-1 subtype C and 2 HIV-1 subtype B sequences. Highly conserved HIV-1 subtype C motifs are outlined. The previously identified RLRR (90-93) motif does not seem to be conserved among our newly analyzed sequences. Conserved motifs can be useful for developing new vaccine strategies or antiretroviral drugs. © 2007 Mary Ann Liebert, Inc.
dc.description.versionArticle
dc.identifier.citationAIDS Research and Human Retroviruses
dc.identifier.citation24
dc.identifier.citation7
dc.identifier.issn8892229
dc.identifier.other10.1089/aid.2008.0077
dc.identifier.urihttp://hdl.handle.net/10019.1/12587
dc.subjectapolipoprotein B messenger RNA editing enzyme catalytic polypeptide 3F
dc.subjectapolipoprotein B messenger RNA editing enzyme catalytic polypeptide 3G
dc.subjectVif protein
dc.subjectamino acid sequence
dc.subjectarticle
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectfemale
dc.subjecthuman
dc.subjectHuman immunodeficiency virus 1
dc.subjectHuman immunodeficiency virus 1 infection
dc.subjectmale
dc.subjectnucleotide sequence
dc.subjectphylogenetic tree
dc.subjectpolymerase chain reaction
dc.subjectpriority journal
dc.subjectprotein motif
dc.subjectsequence analysis
dc.subjectSouth Africa
dc.subjectunindexed sequence
dc.subjectvirus pathogenesis
dc.subjectAmino Acid Motifs
dc.subjectAmino Acid Sequence
dc.subjectFemale
dc.subjectGene Products, vif
dc.subjectHIV Infections
dc.subjectHIV-1
dc.subjectHumans
dc.subjectMale
dc.subjectMolecular Sequence Data
dc.subjectSequence Alignment
dc.subjectSouth Africa
dc.titleMolecular analysis of HIV type 1 vif sequences from Cape Town, South Africa
dc.typeArticle
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